Natrise 30 Tablet is a medicine used in the treatment of low levels of sodium in the blood. It treats low levels of sodium in the blood, which can result from conditions such as heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormone (SIADH).
Uses :
Treatment of hyponatremia (low sodium levels in the blood): Helps raise sodium levels in adults with conditions where sodium is dangerously low. This can happen in:
Heart failure
Liver disease / cirrhosis
Syndrome of Inappropriate Antidiuretic Hormone (SIADH)
By increasing urine output (without losing sodium), it reduces excess water in the body and improves sodium balance.
Slowing progression of autosomal dominant polycystic kidney disease (ADPKD): It may be used to slow kidney cyst growth and decline in kidney function in adults with rapidly progressing ADPKD
Route & Administration :
Route: Oral (by mouth)
Administration: Swallow whole with water; doses are usually once daily
Therapeutic Classification :
Therapeutic class: Vasopressin receptor antagonist / Electrolyte balance agent
Action class: Vasopressin (V2) receptor antagonist – increases free water excretion without significant loss of sodium or potassium
Composition :
Active ingredient: Tolvaptan — 30 mg per tablet
Inactive ingredients / excipients: Standard pharmaceutical agents for tablet formulation (binders, fillers, coatings), typical of tolvaptan tablets (not always specified in summary sources)
How It Works :
Tolavaptan in Natrise blocks the effect of vasopressin (antidiuretic hormone), reducing water reabsorption in kidneys, leading to increased urine production (aquaresis) and raised serum sodium levels without significant loss of electrolytes.
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