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Diabetes & chronic weight management

TIZARO TIRZEPATIDE 2.5mg BUY IN USA, CANADA, SINGAPORE, AUSTRALIA Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Type 2 Diabetes Management TIZARO 2.5mg is used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It enhances insulin secretion and reduces glucagon levels in a glucose-dependent manner. Additionally, it improves insulin sensitivity, aiding in more effective glucose utilization . Weight Management While not officially approved for weight loss, tirzepatide has shown potential in reducing body weight. It may suppress appetite, slow gastric emptying, and increase satiety, which can be beneficial for overweight individuals, particularly those with metabolic disorders Enhancing glucose-dependent insulin secretion Suppressing glucagon Improving insulin sensitivity Delaying gastric emptying to control blood sugar levels Chronic Weight Management Approved for obesity and overweight individuals with comorbidities, due to its: Appetite suppression and increased satiety Slower gastric emptying Significant fat and weight loss demonstrated in clinical trials Cardiovascular & Metabolic Benefits Lowers blood pressure and improves lipid profile Reduces inflammatory markers linked to metabolic syndrome Dosage Details (2.5 mg) Starting dose: 2.5 mg subcutaneous injection once weekly for approximately 4 weeks to minimize GI side effects Administration sites: Abdomen, thigh, or upper arm; consistent day each week BUY NOW FROM US WITH BEST DEALS & OFFERS

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NAD+ & Mitochondrial Support Peptides

Contact Us on telegram or WhatsApp +917887449821‬ +919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ MOTS-c (5mg) :- MOTS-c (5mg), a mitochondrial-derived peptide, is being investigated for its potential to treat metabolic disorders, improve muscle function, and promote healthy aging. It's believed to play a role in regulating energy metabolism, insulin resistance, and the inflammatory response. While research is ongoing, MOTS-c is being explored as a potential therapeutic strategy for conditions like obesity, age-related diseases, and even osteoporosis. MOTS-c stands for 'Mitochondrial Open Reading Frame of the 12S rRNA-c'. It is a 16-amino acid peptide that acts like a hormone, influencing metabolism, stress response, and cellular energy production. Unlike other peptides, it originates from mitochondrial DNA, not nuclear DNA. Exercise and Aging: MOTS-c can enhance exercise endurance and potentially counteract age-related muscle decline Bone Health: Osteoporosis: MOTS-c has been shown to inhibit osteoclast activity and reduce bone loss, suggesting a potential role in preventing and treating osteoporosis. Other Potential Benefits: Anti-inflammatory Effects: MOTS-c may help regulate the inflammatory response, which is implicated in various diseases. Brain Health: Research indicates MOTS-c may improve cognitive function and memory. Cardiovascular Health: MOTS-c has been linked to improved heart function and blood vessel health. 🧠 1. Anti-Aging & Longevity Increases mitochondrial efficiency. Activates AMPK (AMP-activated protein kinase), a key longevity pathway. Promotes cellular stress resistance (e.g., oxidative and metabolic stress). ⚡ 2. Metabolic Health Improves insulin sensitivity and glucose metabolism. Supports weight loss and fat oxidation. Reduces markers of metabolic syndrome and type 2 diabetes in animal models. 💪 3. Exercise & Performance Enhancement Enhances endurance and physical capacity. Protects muscles from exercise-induced stress. Mimics some effects of exercise even without activity ('exercise mimetic'). 🧬 4. Mitochondrial Health Promotes mitochondrial biogenesis. Helps maintain mitochondrial DNA integrity and function under stress. 🧠 5. Neuroprotection (early-stage research) May protect brain cells from oxidative and metabolic damage. MOTS-c (5mg) fast delivery in london

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Metabolic & Weight Management Peptides

Tirzepatide (20mg) Peptide Science |USES|DOSES|SIDE EFFECT FAST DELIVERY TO UNITED KINGDOM Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://wa.me/c/917499402610 Tirzepatide (20mg) USES : -Tirzepatide injection is used to treat type 2 diabetes. It is used together with diet and exercise to help control your blood sugar. Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide is a next-generation medication that acts as a dual agonist of GLP-1 and GIP receptors. It is approved for medical use under the brand name Mounjaro and is also available from research peptide sources (often as a 20mg vial). Chronic Weight Management (Obesity/Overweight) Approved by the FDA in 2023 under the name Zepbound For adults with: BMI ≥30, or BMI ≥27 with weight-related conditions (e.g., hypertension, sleep apnea, dyslipidemia) Shown in clinical trials to result in >20% average body weight loss at higher doses Studying fat loss mechanisms Investigating insulin resistance Testing combination therapy potential with GLP-1 analogs Exploring impacts on metabolic syndrome, NAFLD, and cardiovascular biomarkers 💉 Dosing Guidance (Clinical Reference) Week Typical Dose Weeks 1–4 2.5 mg weekly Weeks 5–8 5 mg weekly Weeks 9+ Increase by 2.5 mg every 4 weeks up to 15 mg weekly (max dose for Mounjaro/Zepbound) FAST DELIVERY IN UNITED KINGDOM FROM SKYBLUE INTERNATIONAL

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Growth Hormone Secretagogues

Tesamorelin (5mg) :- USA FAST DELIVERY Tesamorelin injection is a hormone similar to the one normally released from the hypothalamus gland in the brain. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. Tesamorelin injection is used to decrease the amount of extra fat in the stomach area in adults with human immunodeficiency virus (HIV) who have lipodystrophy (increased body fat in certain areas of the body). Tesamorelin injection is not used to help with weight loss. EXPORT FROM SKYBLUE INTERNATIONAL Reduced body fat, improved cardiovascular health, and cholesterol management. Purpose: Tesamorelin is approved for reducing excess abdominal fat in patients with HIV-associated lipodystrophy. Mechanism: It stimulates the pituitary gland to secrete growth hormone, which reduces visceral (deep abdominal) fat. General Visceral Fat Reduction For obese patients or those with metabolic syndrome, though not yet approved for this indication. EXPORT FROM SKYBLUE INTERNATIONAL How quickly does tesamorelin work? Within 1-2 weeks.

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Growth Hormone Secretagogues

The first 29 amino acids of GHRH were discovered to be as equally potent as its full 44 amino acid structure[1][2] This fragment became known as GRF (1-29). However, due to a rapid metabolic clearance analogues of GRF (1-29) were synthesized to enhance the biological activity and reduce the rapidity of metabolic clearance. These analogues were primarily created by substituting amino acids within the peptide structure for amino acids more resistant to enzymatic cleavage. One early analogue substituted the amino acid L-alanine (abbreviated as Ala or A) at the 2nd position of the peptide structure for its optical isomer (mirror image), D-alanine (abbreviated as D-Ala). This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment.[3][4] This successful modification prompted the further creation of analogues with additional amino acid substitutions. Ipamorelin: A selective growth hormone secretagogue, Ipamorelin stimulates the release of GH by mimicking ghrelin's action on the ghrelin receptor. It is known for its specificity and minimal side effects compared to other GH-releasing peptides. Mod GRF 1-29 (CJC-1295 without DAC): This is a modified version of the first 29 amino acids of growth hormone-releasing hormone (GHRH). The modifications extend its half-life and enhance its ability to stimulate the pituitary gland to release GH. It is often used in research to study GH secretion patterns and related metabolic effects. ⚖️ Dosage and Composition The 5/5 mg blend indicates that each vial contains 5 mg of Mod GRF 1-29 and 5 mg of Ipamorelin, totaling 10 mg per vial. This combination is designed to provide a balanced stimulation of GH release, potentially offering synergistic effects when used in research protocols. 🔬 Research Applications In scientific studies, this peptide blend is utilized to: Study Growth Hormone Dynamics: Investigating the patterns and regulation of GH secretion. Metabolic Research: Understanding the role of GH in metabolism, including fat metabolism and muscle growth. Aging and Longevity Studies: Exploring the effects of GH on aging processes and potential therapeutic applications. Sleep and Recovery Research: Examining how GH influences sleep patterns and recovery processes. ⚠️ Important Considerations Research Use Only: These peptides are intended strictly for laboratory research and are not approved for human or veterinary use. Legal Status: The legality of purchasing and possessing these peptides varies by country and jurisdiction. It's essential to consult local regulations before acquiring them. Storage and Handling: Proper storage conditions are crucial to maintain peptide stability. Typically, lyophilized peptides should be stored at -20°C or colder and protected from light. Reconstitution should be done with appropriate solvents, and solutions should be stored at 4°C and used within a specified timeframe. Mod GRF 1-29 + Ipamorelin (5/5 mg) is primarily used in scientific research and clinical studies to investigate its effects on human growth hormone (GH) release and related metabolic functions. It is not FDA-approved for general medical use, but here are the commonly researched uses and potential applications: Stimulation of Growth Hormone (GH) Release Both peptides work synergistically to enhance the natural pulsatile release of GH from the pituitary gland. Mod GRF 1-29 initiates GH release, while Ipamorelin amplifies it by mimicking ghrelin. Anti-Aging Studies GH has regenerative effects on tissues, so researchers study this combo to explore its potential for: Improving skin elasticity Increasing energy levels Enhancing sleep quality Muscle Growth and Recovery (in studies) GH can help stimulate muscle protein synthesis and recovery. This combo is sometimes researched for its effects on lean muscle mass and exercise recovery. Fat Loss & Metabolic Support GH mobilizes stored fat, making this blend of interest in obesity and metabolic syndrome research. May support lipolysis (fat breakdown) in clinical models. Bone Density Studies GH supports bone mineralization. This combo is explored for potential applications in osteopenia/osteoporosis research. Sleep Improvement GH release is tied to deep sleep stages; researchers observe whether this combo improves sleep architecture and REM sleep. Modified GRF (1-29) acts to increase growth hormone production and release by binding to the growth-hormone-releasing hormone receptor (GHRHR) on cells in the anterior pituitary.

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Growth Hormone Secretagogues

Tesamorelin + CJC-1295 + Ipamorelin (6/3/3mg) FAST DELIVERY TO DOORSTEPS CJC-1295 is an incredibly effective peptide which works by stimulating the release of your own body's growth hormones (which drop quickly after the age of 30). Research has shown that CJC-1295 can increase growth hormone levels by 200-1000% and the elevated growth hormone production continued for up to 6 days. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Powder for Solution. Conclusion: Treatment with tesamorelin was generally well tolerated and resulted in sustained decreases in VAT and triglycerides over 52 weeks without aggravating glucose. Though effects on VAT are sustained during treatment for 52 weeks, these effects do not last beyond the duration of treatment. Signs of high blood sugar like confusion, feeling sleepy, unusual thirst or hunger, passing urine more often, flushing, fast breathing, or breath that smells like fruit. A fast heartbeat. Dizziness or passing out. Flushing. 1. Primary Medical & Performance Uses A. Fat Loss (Especially Visceral Fat) ✅ Tesamorelin (6mg): FDA-approved for HIV lipodystrophy (reduces abdominal fat). Targets stubborn belly fat even in non-HIV patients. ✅ CJC-1295 (3mg) + Ipamorelin (3mg): Amplifies growth hormone (GH) pulses for enhanced fat metabolism. Preserves muscle during calorie deficits. B. Muscle Growth & Recovery Boosts IGF-1 levels → Increases protein synthesis. Accelerates repair of tendons/ligaments (ideal for athletes). C. Anti-Aging & Longevity Improves skin elasticity (collagen stimulation). Enhances sleep quality (GH promotes deep sleep cycles). May support cognitive function (neuroprotective effects). D. Metabolic Health Improves insulin sensitivity (beneficial for prediabetes/metabolic syndrome). Lowers triglycerides (cardiovascular support). 2. Mechanism of Action Peptide Target Effect Tesamorelin GHRH Receptor (Pituitary) Stimulates GH release, specifically reduces visceral fat. CJC-1295 GHRH Receptor (Pituitary) Long-acting GH release (elevates IGF-1 for days). Ipamorelin Ghrelin Receptor Selective GH boost (no cortisol/prolactin spikes). Synergy: Tesamorelin targets fat stores, while CJC-1295 + Ipamorelin prolong GH benefits for muscle and recovery. 3. Dosage & Administration Standard Protocol Blend Ratio: 6mg Tesamorelin + 3mg CJC-1295 + 3mg Ipamorelin per vial. Daily Dose: Tesamorelin: 1–2mg/day (e.g., 1mg AM, 1mg PM). CJC-1295 + Ipamorelin: 100–300mcg each, 1–2x/day (post-workout or bedtime). Cycle Length: 8–12 weeks (followed by 4-week break). Reconstitution Mix with 2–3mL bacteriostatic water (for precise dosing). Storage: Refrigerate after reconstitution (stable for 4–6 weeks). 4. Expected Results & Timeline 📌 Weeks 1–4: Reduced bloating, improved sleep, increased energy. 📌 Weeks 4–8: Visible fat loss (especially abdomen), faster workout recovery. 📌 Weeks 8–12: Lean muscle definition, tighter skin, enhanced endurance. (Optimal with strength training + low-sugar diet.) Final Verdict ✅ Best for: Men/women targeting stubborn belly fat. Athletes wanting muscle preservation + recovery. Anti-aging (skin, cognition, longevity). Description Tesamorelin injection is a hormone similar to the one normally released from the hypothalamus gland in the brain. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Description Tesamorelin injection is a hormone similar to the one normally released from the hypothalamus gland in the brain. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tesamorelin may sometimes be given at home to patients who do not need to be in a hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine. Tesamorelin injection comes with a patient information leaflet and patient instructions. Read the instructions and make sure you understand: How to prepare the injection. Proper use of disposable syringes. How to give the injection. How long the injection is stable. WE EXPORTY TO USA WE EXPORT TO UK WE EXPORT LO CANADA WE EXORT TO AUSTRALIA WE EXPORT ITALY WE EXPORT TO SINGAPORE

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Growth Hormone Secretagogues

Tesamorelin injection is a hormone similar to the one normally released from the hypothalamus gland in the brain. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. Tesamorelin + Ipamorelin (6mg/2mg) Blend: Medical Uses & Applications This peptide combination is primarily used for metabolic, anti-aging, and body composition benefits. Here’s a breakdown of its primary medical and off-label uses: 1. Approved Medical Use (FDA-Approved for HIV Lipodystrophy) ✅ Tesamorelin (6mg) FDA-approved to treat HIV-associated lipodystrophy (excess belly fat caused by antiretroviral therapy). Mechanism: Stimulates growth hormone (GH) release, reducing visceral fat. 2. Off-Label & Research-Based Uses A. Fat Loss & Metabolic Health Visceral fat reduction (even in non-HIV patients). Improves insulin sensitivity (potential for metabolic syndrome/type 2 diabetes support). B. Muscle Growth & Recovery Ipamorelin (2mg) is a growth hormone secretagogue (GHS) that: Boosts lean muscle mass. Enhances post-workout recovery. C. Anti-Aging & Longevity Increases collagen production (improves skin elasticity). May support cognitive function (GH plays a role in brain health). D. Injury & Tissue Repair Accelerates healing of tendons/ligaments (used by athletes). 3. Typical Treatment Protocol Dosage: Tesamorelin: 1-2mg/day (often 6mg total per week). Ipamorelin: 200-300mcg/day (2mg total per week). Administration: Subcutaneous injections (stomach or thigh). Cycle Length: 8-12 weeks (with breaks to avoid GH desensitization). 4. Key Benefits vs. Other Peptides Peptide Primary Use Pros Cons Tesamorelin FDA-approved fat loss Targets stubborn belly fat Expensive, requires prescri Final Verdict This blend is best for: ✔ Men/women targeting stubborn fat (especially abdominal). ✔ Athletes seeking muscle recovery & anti-aging benefits. ✔ Those wanting a safer alternative to synthetic GH. 4. Typical Dosage & Protocol Tesamorelin: 1-2mg/day (or 6mg/week). Ipamorelin: 200-300mcg/day (or 2mg/week). Administration: Subcutaneous injection (stomach/thigh). Cycle Length: 8-12 weeks (followed by a break to avoid GH resistance). 3. How It Works Tesamorelin → Stimulates pituitary GH release → Reduces visceral fat. 5. Expected Results & Timeline 📌 4-6 Weeks: Reduced belly fat, improved energy. 📌 8-12 Weeks: Visible muscle definition, better skin elasticity. 📌 Beyond 3 Months: Enhanced recovery, potential cognitive benefits. 5. Expected Results & Timeline 📌 4-6 Weeks: Reduced belly fat, improved energy. 📌 8-12 Weeks: Visible muscle definition, better skin elasticity. 📌 Beyond 3 Months: Enhanced recovery, potential cognitive benefits. 5. Expected Results & Timeline 📌 4-6 Weeks: Reduced belly fat, improved energy. 📌 8-12 Weeks: Visible muscle definition, better skin elasticity. 📌 Beyond 3 Months: Enhanced recovery, potential cognitive benefits. (Best when combined with diet + exercise) . Rare (serious): Increased blood sugar (caution for diabetics). Carpal tunnel syndrome (high doses). Final Verdict ✅ Best for: Men/women struggling with belly fat. Athletes seeking muscle recovery + anti-aging. Those wanting GH benefits without synthetic HGH risks. ❌ Not for: Quick fixes – requires consistent use for 2-3 months Tesamorelin, known for reducing abdominal fat in HIV patients with lipodystrophy, together with Ipamorelin, a growth hormone-releasing peptide, can enhance overall body composition improvements. Furthermore, both substances may work synergistically to boost muscle growth, fat loss, recovery, and anti-aging effects, maximizing the benefits of each peptide when used in tandem. Before taking this medicine You should not use tesamorelin if you are allergic to it, or if you have: cancer; a pituitary gland disorder; a history of pituitary gland tumor or surgery; a history of head injury or radiation treatment; or if you are pregnant. To make sure you can safely take tesamorelin, tell your doctor if you have any of these other conditions: a history of cancer or any tumor (either benign or malignant); heart disease, high blood pressure; kidney disease; diabetes, eye problems caused by diabetes; epilepsy asthma; migraine headaches; adrenal gland disorder; if you have ever had open heart surgery; or if you have any major illness, a recent trauma, or a medical emergency. FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use tesamorelin if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. WE EXPORT IN USA WE EXPORT IN UK WE EXPORT IN AUSTRALIA WE EXPORT IN CANADA WE EXPORT IN SINGAPORE

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Chronic Pain Treatment

Tapaday tapentadol 250mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, EUROPE, UAE WORLD WIDE SHIPPING Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Drug Name Tapady (Tapentadol 250 mg) Form Likely Extended Release (ER) Tablet Used for Severe chronic or cancer pain, advanced neuropathic pain 🔹 1. Severe Chronic Pain Conditions: Long-standing musculoskeletal pain Severe osteoarthritis Advanced joint or spine degeneration 🔹 2. Cancer-Related Pain (Palliative Care): Patients with advanced cancer pain who need strong opioids around the clock When morphine or fentanyl is not well tolerated 🔹 3. Neuropathic Pain (Advanced Cases): Severe diabetic neuropathy Sciatica or nerve compression syndromes resistant to lower opioid therapy Usually Extended-Release (ER) Tapentadol 250mg SHIPPING WORLD WIDE FAST DELIVERY IN USA FOR Tapentadol 250mg FAST DELIVERY IN UK FOR PTapentadol 250mg FAST DELIVERY IN UAE FOR Tapentadol 250mg BUY IN AUSTRALIA BUY IN UNITED KINGDOM BUY IN USA BUY IN SINGAPORE SHIPPING WORLD WIDE

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Chronic Pain Treatment

Tapaday tapentadol 200mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, EUROPE, UAE Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.medicinesfromindia.com/ 1. Chronic Severe Pain Long-term management of conditions where daily, round-the-clock opioid treatment is necessary. Example: Chronic low back pain, severe osteoarthritis, or post-surgical chronic pain. 2. Neuropathic Pain Especially in cases like: Diabetic peripheral neuropathy Nerve compression syndromes (sciatica, spinal nerve root pain) 3. Cancer-Related Pain Used in palliative care when pain is persistent and intense. 💊 Formulation: Usually in Extended-Release (ER) tablets Provides 12–24 hour pain relief BUY IN USA PURCHASE IN USA WORLD WIDE SHIPPING

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