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'igf1 receptors'

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Sexual & Reproductive Health Peptide

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Generic Name Bremelanotide 1. Hypoactive Sexual Desire Disorder (HSDD) in Women FDA-approved in 2019 under the brand Vyleesi for pre-menopausal women with generalized HSDD unrelated to other medical or psychological condition Improves sexual desire, arousal, and reduces distress linked to low libido 2. Erectile Dysfunction (ED) in Men (Off‑Label) PT‑141 initiates erections via central nervous system pathways, increasing sexual desire and erection quality—even in men unresponsive to PDE‑5 inhibitors Demonstrated increased duration and rigidity of erections in trials 3. Sexual Arousal Support Boosts libido in both genders, addresses low sexual drive and arousal disorders, potentially enhancing orgasm quality and reducing refractory time Bremelanotide is a 7 amino acid peptide used to treat hypoactive sexual desire disorder in premenopausal women. Bremelanotide does not interact with alcohol. The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown. Bremelanotide was first described in the literature in 2003 when it was known by the investigational code PT-141.1 Since then it was investigated for its place in treating sexual dysfunction in men and women but is now only indicated for women.1,2,5 Other drugs used to treat female sexual dysfunction include flibanserin, estrogen, ospemifene, and prasterone. Bremelanotide was granted FDA approval Bremelanotide is an agonist of many melanocortin receptors which in order of potency are MC1R, MC4R, MC3R, MC5R, and MC2R.5 The mechanism by which agonism of these receptors translates to an improvement in hypoactive sexual desire disorder is currently unknown, however MC4R receptors are present in many areas of the central nervous system. MC3R and MC4R are found in the hypothalamus and are involved in food intake and energy homeostasis. Bremelanotide is a 7 amino acid and so its metabolism consists of multiple hydrolysis reactions.

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Neurological & Cognitive Peptides

PEPTIDE Selank 10mg FAST DELIVERY in LONDON Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ USES :- Anxiety Reduction (Anxiolytic Effect) Acts on GABA receptors (like benzodiazepines but without sedation or addiction risk) Reduces symptoms of: Generalized anxiety Social anxiety Stress and tension Cognitive Enhancement (Nootropic) Improves: Focus Mental clarity Memory retention and recall Used for cognitive fatigue and brain fog Improves Mood & Emotional Stability Regulates serotonin and dopamine levels in the brain May help with mild depression and mood swings Immune System Modulation Enhances immune system balance without overstimulation Originally developed in Russia for treating immune-related conditions and infections Neuroprotection Protects neurons from oxidative stress and damage May support recovery after traumatic brain injury or chronic stress

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Metabolic & Weight Management Peptides

Tirzepatide (60mg) FAST DELIVERY TO FLORIDA Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Tirzepatide (60mg) Uses: Type 2 Diabetes: Tirzepatide is used to improve blood sugar control in adults with type 2 diabetes, often used with diet and exercise. Weight Management: It is also used for weight loss, particularly in adults who are overweight or obese, or who have weight-related medical problems. a synthetic peptide, a dual agonist for both GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide) receptors. It is used to treat type 2 diabetes and may also be used for weight management. It works by mimicking the effects of two hormones involved in glucose regulation and appetite control, helping to lower blood sugar levels and potentially leading to weight loss. Tirzepatide is administered as a once-weekly subcutaneous injection. Dual Action: Tirzepatide targets both GLP-1 and GIP receptors, enhancing insulin sensitivity and potentially leading to weight loss. Mechanism of Action: It increases insulin secretion when blood sugar is high, lowers liver glucose production, and slows down food movement through the digestive tract, contributing to blood sugar control and weight loss. Administration: Tirzepatide is a subcutaneous injection, given once weekly. Potential Side Effects: Common side effects include nausea, vomiting, diarrhea, and constipation, especially during the initial dose escalation phase. Top Benefits of Tirzepatide :- Powerful Blood Sugar Control (Type 2 Diabetes) Lowers HbA1c levels significantly (up to 2.4% reduction) Helps regulate insulin and glucagon more effectively than GLP-1 drugs alone Outperforms other drugs like semaglutide and insulin degludec in trials

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Metabolic & Weight Management Peptides

TO BUY Tirzepatide (40mg) Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com Internationalskyblue@gmail.com Viwe our catalog :- https://wa.me/c/917499402610 Tirzepatide is a dual agonist for the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors. The drug leads to significantly improved glycemic control and weight reduction in patients with T2DM, maximizing benefits similar to GLP-1 medications such as semaglutide. Tirzepatide (Zepbound brand) is used for weight loss, to help lose weight and keep weight off. Tirzepatide works for weight loss by decreasing appetite and slowing the movement of food from the stomach into the small intestine, which may make you feel full more quickly and for a longer period. The Zepbound brand of tirzepatide is also used for moderate to severe obstructive sleep apnea (OSA) in adults with obesity. Tirzepatide is a once-weekly injection given under the skin using a pen (autoinjector). Zepbound (tirzepatide) is FDA-approved for weight loss in adults with obesity or who are overweight and have weight-related medical problems or OSA. Zepbound helps you to lose weight and maintain weight loss and should be combined with diet and exercise. Tirzepatide (Mounjaro brand) is used for type 2 diabetes to help improve blood sugar levels. In type 2 diabetes, tirzepatide decreases blood sugar levels by helping release insulin when blood sugar levels are high, lowering the amount of sugar the liver makes, and slowing food movement through the intestines. Mounjaro should be used together with diet and exercise. Mounjaro (tirzepatide) is FDA-approved to treat adults with type 2 diabetes and should be used together with diet and exercise. It can be used as a single therapy (on its own) or with other diabetes medicines, including sulfonylureas, SGLT2 inhibitors, or metformin. It is not known if tirzepatide can be used in people who have had pancreatitis. Tirzepatide should not be used in people who have type 1 diabetes. Normally, when we eat, natural hormones called GIP and GLP-1 are released by the gut. These hormones increase insulin release, suppress appetite, slow gastric emptying, and increase the feeling of fullness. Tirzepatide works like our natural hormones GIP and GLP-1 by activating the GIP and GLP-1 receptors. Tirzepatide is a GIP and GLP-1 receptor agonist. Tirzepatide works (mechanism of action) by activating both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors. Weight Loss Achieved: tirzepatide: 64.6% of participants lost 15% of their weight semaglutide: 40.1% of participants lost 15% of their weighT Tirzepatide (40mg) USE FOR WEIGHT LOSS Mechanisms: Increases insulin release in response to glucose Reduces glucagon secretion Slows digestion to avoid sugar spikes

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Metabolic & Weight Management Peptides

Tirzepatide (20mg) Peptide Science |USES|DOSES|SIDE EFFECT FAST DELIVERY TO UNITED KINGDOM Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://wa.me/c/917499402610 Tirzepatide (20mg) USES : -Tirzepatide injection is used to treat type 2 diabetes. It is used together with diet and exercise to help control your blood sugar. Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide is a next-generation medication that acts as a dual agonist of GLP-1 and GIP receptors. It is approved for medical use under the brand name Mounjaro and is also available from research peptide sources (often as a 20mg vial). Chronic Weight Management (Obesity/Overweight) Approved by the FDA in 2023 under the name Zepbound For adults with: BMI ≥30, or BMI ≥27 with weight-related conditions (e.g., hypertension, sleep apnea, dyslipidemia) Shown in clinical trials to result in >20% average body weight loss at higher doses Studying fat loss mechanisms Investigating insulin resistance Testing combination therapy potential with GLP-1 analogs Exploring impacts on metabolic syndrome, NAFLD, and cardiovascular biomarkers 💉 Dosing Guidance (Clinical Reference) Week Typical Dose Weeks 1–4 2.5 mg weekly Weeks 5–8 5 mg weekly Weeks 9+ Increase by 2.5 mg every 4 weeks up to 15 mg weekly (max dose for Mounjaro/Zepbound) FAST DELIVERY IN UNITED KINGDOM FROM SKYBLUE INTERNATIONAL

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Metabolic & Weight Management Peptides

Retatrutide 16mg is being developed to target multiple metabolic conditions, with its primary uses in obesity management, type 2 diabetes, and fatty liver disease. Retatrutide is an investigational triple hormone receptor agonist (GLP-1, GIP, and glucagon receptors) Main Uses of Retatrutide 1. Obesity Treatment Primary target: Adults with obesity (BMI ≥30) or overweight (BMI ≥27) with a weight-related condition. Effectiveness: Up to 24.2% body weight loss at the highest tested dose (12 mg) over 48 weeks. Outperformed semaglutide (Wegovy) and tirzepatide (Zepbound) in trials. Mechanism: Appetite suppression Slowed gastric emptying Increased energy expenditure Type 2 Diabetes Management Improves blood glucose control by: Enhancing insulin sensitivity Increasing insulin secretion Reducing glucagon levels (in a glucose-dependent way) Massive reductions in liver fat (up to 82.4% in some patients) Helps improve: Liver enzyme profiles (ALT, AST) Hepatic insulin resistance SKYBLUE INTERNATIONAL is a trusted global pharmaceutical export company specializing in the export of high-quality medicines. With a strong commitment to healthcare excellence, we supply a wide range of branded and generic medicines to countries including the USA, UK, Australia, UAE, Canada, Singapore, and the Philippines. Our focus is on reliability, compliance, and timely delivery to meet the global demand for affordable and effective medical solutions. Medicine 💊 Retatrutide (16mg) BUY FROM SKYBLUE INTERNATIONAL Weight reduction Improved insulin sensitivity Hormonal balancing

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Metabolic & Weight Management Peptides

Retatrutide (10mg) USA FAST DELIVERY Retatrutide (10mg : - Obesity and Overweight Management Retatrutide has demonstrated significant efficacy in promoting weight loss. In clinical trials, participants have achieved up to 24.2% weight loss over 48 weeks, outperforming existing treatments like semaglutide and tirzepatide. Form: Subcutaneous injection (once weekly) Dose Titration: To reduce side effects (especially GI issues), dosing typically starts low and increases over time. What Is Retatrutide Used For? Retatrutide is being developed to target multiple metabolic conditions, with its primary uses in obesity management, type 2 diabetes, and fatty liver disease. Retatrutide activates the GIP, GLP-1 and glucagon receptors that are involved with controlling hunger and satiety, allowing people to feel fuller after eating for longer. This helps to regulate blood sugar levels, leading to weight loss. Non-Alcoholic Fatty Liver Disease (NAFLD) Retatrutide has led to significant reductions in liver fat in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), with reductions up to 82.4% observed in clinical trials. Target Population Adults with obesity (BMI ≥30) or overweight (BMI ≥27) with comorbidities (e.g., type 2 diabetes, hypertension) Adults with type 2 diabetes, especially those who need better weight and glucose control EXPORT FROM INDIA IN CHEAPEST PRICE. Retatrutide is an investigational drug still in clinical trials and has not yet been approved by the FDA for general use. However, based on Phase 2 clinical trials.

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Growth Hormone Secretagogues

CJC-1295 DAC (5mg) FAST DELIVERY TO AUSTRALIA SKYBLUE INTERNATIONAL is a trusted global pharmaceutical export company specializing in the export of high-quality medicines. With a strong commitment to healthcare excellence, we supply a wide range of branded and generic medicines to countries including the USA, UK, Australia, UAE, Canada, Singapore, and the Philippines. Our focus is on reliability, compliance, and timely delivery to meet the global demand for affordable and effective medical solutions. Medicine 💊 USES : CJC-1295 DAC (Drug Affinity Complex) is a long-acting growth hormone-releasing hormone (GHRH) analog designed to elevate IGF-1 and growth hormone (GH) levels for days after a single injection. Below is a detailed breakdown of its primary applications, mechanisms, and protocols. Fat Loss & Metabolism Boosts lipolysis (fat breakdown), especially stubborn visceral fat. Improves insulin sensitivity → Supports metabolic health. Mechanism: Binds to GHRH receptors in the pituitary → sustained GH release (elevates IGF-1 for 5-7 days per dose). Half-life: 6-8 days (due to DAC modification, which prevents rapid breakdown). Key Difference vs. CJC-1295 (no DAC): CJC-1295 DAC → Long-lasting effects (fewer injections needed). Standard CJC-1295 → Shorter duration (requires daily dosing). Standard Protocol (5mg Vial) Reconstitution: Mix with 2mL bacteriostatic water (yields 2.5mg/mL). Dosing: Beginner: 1mg (0.4mL) 2x/week (e.g., Monday & Thursday). Advanced: 2mg (0.8mL) 2x/week (for maximum IGF-1 elevation). Cycle Length: 8-12 weeks (followed by a 4-week break). ✅ Best for: Athletes wanting sustained muscle growth & recovery. Men/women targeting fat loss + anti-aging benefits. Those who prefer fewer injections (vs. daily peptides). WE EXPORT IN UK WE EXPORT IN SINGAPORE WE EXPORT IN DUBAI WE EXPORT IN JAPAN WE EXPORT IN CANADA

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Growth Hormone Secretagogues

Ipamorelin works by binding to IGF-1 receptors in the body and mimicking its effects on those receptors. This causes an increase in muscle mass and strength, as well as fat loss due to increased metabolism and lipolysis (the breakdown of fat). Semorelin + Ipamorelin (5mg/5mg) – Key Uses, Benefits & Protocol This growth hormone (GH)-stimulating peptide blend is used for anti-aging, fat loss, muscle growth, and recovery. 1. Primary Uses A. Anti-Aging & Longevity Boosts collagen → Improves skin elasticity, reduces wrinkles. Enhances sleep quality → Deepens REM sleep for cellular repair. Supports cognitive function → May improve memory/focus. B. Fat Loss & Metabolism Reduces stubborn fat (especially visceral/belly fat). Improves insulin sensitivity → Helps with metabolic disorders. C. Muscle Growth & Recovery Increases lean muscle mass (without water retention). Speeds up injury recovery (tendons, ligaments, joints). D. Performance Enhancement (Athletes/Bodybuilders) Enhances workout recovery → Less soreness, faster gains. Preserves muscle during cutting phases. 2. How It Works Sermorelin → Stimulates natural GH release from the pituitary. Ipamorelin → A selective GH secretagogue (avoids cortisol/prolactin spikes). Synergy: More sustained GH pulses than either peptide alone. (Unlike synthetic HGH, this combo promotes natural, balanced GH secretion.) 3. Dosage & Administration Standard Dose: 5mg Sermorelin + 5mg Ipamorelin per vial (mixed with bacteriostatic water). Daily Injection: 100-300mcg each (e.g., 100mcg Sermorelin + 100mcg Ipamorelin). Typically 1-2 injections/day (morning and/or before bed). Cycle Length: 8-12 weeks (then take a 4-week break). 4. Expected Results & Timeline 📌 4-6 Weeks: Better sleep, increased energy, reduced body fat. 📌 8-12 Weeks: Visible muscle tone, tighter skin, faster recovery. 📌 3+ Months: Long-term anti-aging benefits (if cycled properly). (Best paired with strength training + high-protein diet.) 7. Alternatives to Consider Peptide Best For Pros Cons Tesamorelin + Ipamorelin Fat loss (visceral) FDA-approved (for HIV lipodystrophy) Expensive Final Verdict ✅ Best for: Anti-aging (skin, cognition, longevity). Athletes seeking muscle growth + recovery. Men/women targeting stubborn fat. . Detailed Benefits & Science How it compares to HGH or other peptides (like CJC-1295). Anti-aging mechanisms (collagen, cellular repair). 2. Cycle Recommendations Optimal dosing (e.g., 100mcg vs. 300mcg per day). How long to run it (8 vs. 12 weeks). 5. Success Stories/User Experiences Real-world results for fat loss, muscle gain, or skin improvement. Increased energy levels: sermorelin and ipamorelin help boost energy and stamina, allowing you to feel more active and engaged throughout the day. Improved sleep quality: By enhancing restorative sleep, sermorelin and ipamorelin can lead to better overall health and well-being. Sermorelin is a peptide hormone that is structurally similar to growth hormone-releasing hormone (GHRH). It is typically used to treat growth hormone deficiency in children and adults. It can also be used for other conditions, such as improving wound healing, reducing fat mass, and increasing muscle mass. Sermorelin and Ipamorelin peptides are often combined because they have synergistic properties. Research has proven them to help slow down the aging process, increase muscle mass, decrease fat mass, reduce inflammation, heal the gut and more. How often should I take Sermorelin? A dosage of 0.2-0.3 mcg once daily at bedtime by subcutaneous injection is recommended. Ipamorelin is a peptide that has been shown to increase growth hormone levels in humans by stimulating the hypothalamus, which is responsible for regulating the secretion of growth hormone. Ipamorelin works by binding to IGF-1 receptors in the body and mimicking its effects on those receptors. This causes an increase in muscle mass and strength, as well as fat loss due to increased metabolism and lipolysis (the breakdown of fat). When Can I Expect To See Results? While patients will notice some significant increases changes in the body after the first month, the full-benefits are usually fully noticed after three to six months of therapy. Month 1 * Increased energy * Improved stamina * Deeper, more restful sleep Month 2 * Improved skin, reduced wrinkles * Stronger nails and hair * Increased metabolism Month 3 * Enhanced sex drive and performance * Improved mental focus * Improved joint health Month 4 * Continued weight reduction * Improved skin elasticity * Increased lean muscle mass Month 5 * Noticeably fuller and healthier hair * Reduced appearance of wrinkles, better skin tone * Continued reduction in belly fat Month 6 * 5-10% reduction in body fat (without exercise/diet) * 10% increase in lean muscle mass * Improved vitality due to organ regrowth WE EXPORT TO USA WE EXPORT TO UK WE EXORT TO CANADA WE EXPORT TO SINGAPORE WE EXPORT

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