The first 29 amino acids of GHRH were discovered to be as equally potent as its full 44 amino acid structure[1][2] This fragment became known as GRF (1-29). However, due to a rapid metabolic clearance analogues of GRF (1-29) were synthesized to enhance the biological activity and reduce the rapidity of metabolic clearance. These analogues were primarily created by substituting amino acids within the peptide structure for amino acids more resistant to enzymatic cleavage. One early analogue substituted the amino acid L-alanine (abbreviated as Ala or A) at the 2nd position of the peptide structure for its optical isomer (mirror image), D-alanine (abbreviated as D-Ala). This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment.[3][4] This successful modification prompted the further creation of analogues with additional amino acid substitutions. Ipamorelin: A selective growth hormone secretagogue, Ipamorelin stimulates the release of GH by mimicking ghrelin's action on the ghrelin receptor. It is known for its specificity and minimal side effects compared to other GH-releasing peptides. Mod GRF 1-29 (CJC-1295 without DAC): This is a modified version of the first 29 amino acids of growth hormone-releasing hormone (GHRH). The modifications extend its half-life and enhance its ability to stimulate the pituitary gland to release GH. It is often used in research to study GH secretion patterns and related metabolic effects. ⚖️ Dosage and Composition The 5/5 mg blend indicates that each vial contains 5 mg of Mod GRF 1-29 and 5 mg of Ipamorelin, totaling 10 mg per vial. This combination is designed to provide a balanced stimulation of GH release, potentially offering synergistic effects when used in research protocols. 🔬 Research Applications In scientific studies, this peptide blend is utilized to: Study Growth Hormone Dynamics: Investigating the patterns and regulation of GH secretion. Metabolic Research: Understanding the role of GH in metabolism, including fat metabolism and muscle growth. Aging and Longevity Studies: Exploring the effects of GH on aging processes and potential therapeutic applications. Sleep and Recovery Research: Examining how GH influences sleep patterns and recovery processes. ⚠️ Important Considerations Research Use Only: These peptides are intended strictly for laboratory research and are not approved for human or veterinary use. Legal Status: The legality of purchasing and possessing these peptides varies by country and jurisdiction. It's essential to consult local regulations before acquiring them. Storage and Handling: Proper storage conditions are crucial to maintain peptide stability. Typically, lyophilized peptides should be stored at -20°C or colder and protected from light. Reconstitution should be done with appropriate solvents, and solutions should be stored at 4°C and used within a specified timeframe. Mod GRF 1-29 + Ipamorelin (5/5 mg) is primarily used in scientific research and clinical studies to investigate its effects on human growth hormone (GH) release and related metabolic functions. It is not FDA-approved for general medical use, but here are the commonly researched uses and potential applications: Stimulation of Growth Hormone (GH) Release Both peptides work synergistically to enhance the natural pulsatile release of GH from the pituitary gland. Mod GRF 1-29 initiates GH release, while Ipamorelin amplifies it by mimicking ghrelin. Anti-Aging Studies GH has regenerative effects on tissues, so researchers study this combo to explore its potential for: Improving skin elasticity Increasing energy levels Enhancing sleep quality Muscle Growth and Recovery (in studies) GH can help stimulate muscle protein synthesis and recovery. This combo is sometimes researched for its effects on lean muscle mass and exercise recovery. Fat Loss & Metabolic Support GH mobilizes stored fat, making this blend of interest in obesity and metabolic syndrome research. May support lipolysis (fat breakdown) in clinical models. Bone Density Studies GH supports bone mineralization. This combo is explored for potential applications in osteopenia/osteoporosis research. Sleep Improvement GH release is tied to deep sleep stages; researchers observe whether this combo improves sleep architecture and REM sleep. Modified GRF (1-29) acts to increase growth hormone production and release by binding to the growth-hormone-releasing hormone receptor (GHRHR) on cells in the anterior pituitary.

Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://wa.me/c/917499402610 Name Semaglutide Purity ≥98% (as tested by HPLC, High-Performance Liquid Chromatography) CAS Number 910463-68-2 Molecular Formula C₁₈₇H₂₉₁N₄₅O₅₉ Molecular Weight ~4113.58 g/mol Peptide Sequence Modified GLP-1 (7-37) analog with substitutions to enhance stability Form Lyophilized powder (freeze-dried) Content 3mg per vial Semaglutide is a medication originally developed for type 2 diabetes and obesity treatment. It's a GLP-1 receptor agonist, meaning it mimics the hormone GLP-1, which helps regulate blood sugar and appetite. Type 2 Diabetes Management Lowers blood sugar by increasing insulin release and reducing glucagon secretion. Helps patients achieve better glycemic control. Weight Loss (Obesity or Overweight with Comorbidities) Reduces appetite and slows gastric emptying. FDA-approved under the brand name Wegovy for chronic weight management. 💉 Semaglutide 3mg – Dosing Guide (Research and Clinical Context) ✅ Clinically Approved Dosing (Prescription Use) Under brand names like Ozempic (for diabetes) and Wegovy (for weight loss), the FDA-approved semaglutide dosing follows this gradual titration to minimize side effects: Week Dose (Subcutaneous Injection) Weeks 1–4 0.25 mg once weekly Weeks 5–8 0.5 mg once weekly Weeks 9–12 1.0 mg once weekly (maintenance or increase as needed) Weeks 13+ 1.7 mg – 2.4 mg weekly (Wegovy max) or up to 2.0 mg (Ozempic max) Route: Subcutaneous injection (abdomen, thigh, or upper arm) Frequency: Once per week, same day/time ⚠️ Important Notes Side Effects: Can include nausea, vomiting, diarrhea, abdominal pain, and risk of pancreatitis. Not for Type 1 Diabetes or Ketoacidosis. Only certain brands and dosages are approved for specific uses.

Tesamorelin + CJC-1295 + Ipamorelin (6/3/3mg) FAST DELIVERY TO DOORSTEPS CJC-1295 is an incredibly effective peptide which works by stimulating the release of your own body's growth hormones (which drop quickly after the age of 30). Research has shown that CJC-1295 can increase growth hormone levels by 200-1000% and the elevated growth hormone production continued for up to 6 days. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Powder for Solution. Conclusion: Treatment with tesamorelin was generally well tolerated and resulted in sustained decreases in VAT and triglycerides over 52 weeks without aggravating glucose. Though effects on VAT are sustained during treatment for 52 weeks, these effects do not last beyond the duration of treatment. Signs of high blood sugar like confusion, feeling sleepy, unusual thirst or hunger, passing urine more often, flushing, fast breathing, or breath that smells like fruit. A fast heartbeat. Dizziness or passing out. Flushing. 1. Primary Medical & Performance Uses A. Fat Loss (Especially Visceral Fat) ✅ Tesamorelin (6mg): FDA-approved for HIV lipodystrophy (reduces abdominal fat). Targets stubborn belly fat even in non-HIV patients. ✅ CJC-1295 (3mg) + Ipamorelin (3mg): Amplifies growth hormone (GH) pulses for enhanced fat metabolism. Preserves muscle during calorie deficits. B. Muscle Growth & Recovery Boosts IGF-1 levels → Increases protein synthesis. Accelerates repair of tendons/ligaments (ideal for athletes). C. Anti-Aging & Longevity Improves skin elasticity (collagen stimulation). Enhances sleep quality (GH promotes deep sleep cycles). May support cognitive function (neuroprotective effects). D. Metabolic Health Improves insulin sensitivity (beneficial for prediabetes/metabolic syndrome). Lowers triglycerides (cardiovascular support). 2. Mechanism of Action Peptide Target Effect Tesamorelin GHRH Receptor (Pituitary) Stimulates GH release, specifically reduces visceral fat. CJC-1295 GHRH Receptor (Pituitary) Long-acting GH release (elevates IGF-1 for days). Ipamorelin Ghrelin Receptor Selective GH boost (no cortisol/prolactin spikes). Synergy: Tesamorelin targets fat stores, while CJC-1295 + Ipamorelin prolong GH benefits for muscle and recovery. 3. Dosage & Administration Standard Protocol Blend Ratio: 6mg Tesamorelin + 3mg CJC-1295 + 3mg Ipamorelin per vial. Daily Dose: Tesamorelin: 1–2mg/day (e.g., 1mg AM, 1mg PM). CJC-1295 + Ipamorelin: 100–300mcg each, 1–2x/day (post-workout or bedtime). Cycle Length: 8–12 weeks (followed by 4-week break). Reconstitution Mix with 2–3mL bacteriostatic water (for precise dosing). Storage: Refrigerate after reconstitution (stable for 4–6 weeks). 4. Expected Results & Timeline 📌 Weeks 1–4: Reduced bloating, improved sleep, increased energy. 📌 Weeks 4–8: Visible fat loss (especially abdomen), faster workout recovery. 📌 Weeks 8–12: Lean muscle definition, tighter skin, enhanced endurance. (Optimal with strength training + low-sugar diet.) Final Verdict ✅ Best for: Men/women targeting stubborn belly fat. Athletes wanting muscle preservation + recovery. Anti-aging (skin, cognition, longevity). Description Tesamorelin injection is a hormone similar to the one normally released from the hypothalamus gland in the brain. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Description Tesamorelin injection is a hormone similar to the one normally released from the hypothalamus gland in the brain. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tesamorelin may sometimes be given at home to patients who do not need to be in a hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine. Tesamorelin injection comes with a patient information leaflet and patient instructions. Read the instructions and make sure you understand: How to prepare the injection. Proper use of disposable syringes. How to give the injection. How long the injection is stable. WE EXPORTY TO USA WE EXPORT TO UK WE EXPORT LO CANADA WE EXORT TO AUSTRALIA WE EXPORT ITALY WE EXPORT TO SINGAPORE