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The first 29 amino acids of GHRH were discovered to be as equally potent as its full 44 amino acid structure[1][2] This fragment became known as GRF (1-29). However, due to a rapid metabolic clearance analogues of GRF (1-29) were synthesized to enhance the biological activity and reduce the rapidity of metabolic clearance. These analogues were primarily created by substituting amino acids within the peptide structure for amino acids more resistant to enzymatic cleavage. One early analogue substituted the amino acid L-alanine (abbreviated as Ala or A) at the 2nd position of the peptide structure for its optical isomer (mirror image), D-alanine (abbreviated as D-Ala). This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment.[3][4] This successful modification prompted the further creation of analogues with additional amino acid substitutions. Ipamorelin: A selective growth hormone secretagogue, Ipamorelin stimulates the release of GH by mimicking ghrelin's action on the ghrelin receptor. It is known for its specificity and minimal side effects compared to other GH-releasing peptides. Mod GRF 1-29 (CJC-1295 without DAC): This is a modified version of the first 29 amino acids of growth hormone-releasing hormone (GHRH). The modifications extend its half-life and enhance its ability to stimulate the pituitary gland to release GH. It is often used in research to study GH secretion patterns and related metabolic effects. ⚖️ Dosage and Composition The 5/5 mg blend indicates that each vial contains 5 mg of Mod GRF 1-29 and 5 mg of Ipamorelin, totaling 10 mg per vial. This combination is designed to provide a balanced stimulation of GH release, potentially offering synergistic effects when used in research protocols. 🔬 Research Applications In scientific studies, this peptide blend is utilized to: Study Growth Hormone Dynamics: Investigating the patterns and regulation of GH secretion. Metabolic Research: Understanding the role of GH in metabolism, including fat metabolism and muscle growth. Aging and Longevity Studies: Exploring the effects of GH on aging processes and potential therapeutic applications. Sleep and Recovery Research: Examining how GH influences sleep patterns and recovery processes. ⚠️ Important Considerations Research Use Only: These peptides are intended strictly for laboratory research and are not approved for human or veterinary use. Legal Status: The legality of purchasing and possessing these peptides varies by country and jurisdiction. It's essential to consult local regulations before acquiring them. Storage and Handling: Proper storage conditions are crucial to maintain peptide stability. Typically, lyophilized peptides should be stored at -20°C or colder and protected from light. Reconstitution should be done with appropriate solvents, and solutions should be stored at 4°C and used within a specified timeframe. Mod GRF 1-29 + Ipamorelin (5/5 mg) is primarily used in scientific research and clinical studies to investigate its effects on human growth hormone (GH) release and related metabolic functions. It is not FDA-approved for general medical use, but here are the commonly researched uses and potential applications: Stimulation of Growth Hormone (GH) Release Both peptides work synergistically to enhance the natural pulsatile release of GH from the pituitary gland. Mod GRF 1-29 initiates GH release, while Ipamorelin amplifies it by mimicking ghrelin. Anti-Aging Studies GH has regenerative effects on tissues, so researchers study this combo to explore its potential for: Improving skin elasticity Increasing energy levels Enhancing sleep quality Muscle Growth and Recovery (in studies) GH can help stimulate muscle protein synthesis and recovery. This combo is sometimes researched for its effects on lean muscle mass and exercise recovery. Fat Loss & Metabolic Support GH mobilizes stored fat, making this blend of interest in obesity and metabolic syndrome research. May support lipolysis (fat breakdown) in clinical models. Bone Density Studies GH supports bone mineralization. This combo is explored for potential applications in osteopenia/osteoporosis research. Sleep Improvement GH release is tied to deep sleep stages; researchers observe whether this combo improves sleep architecture and REM sleep. Modified GRF (1-29) acts to increase growth hormone production and release by binding to the growth-hormone-releasing hormone receptor (GHRHR) on cells in the anterior pituitary.

Product introduction Tasigna 200mg Capsule is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects. Tasigna 200mg Capsule should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Headache, nausea, abdominal pain, and rash are very common side effects of this medicine. If you experience severe diarrhea, consult with your doctor or drink plenty of fluids while on treatment. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and blood uric acid levels and blood sugar or fat level in the body. Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy. How to use Tasigna Capsule Take this medicine in the dose and duration as advised by your doctor. Tasigna 200mg Capsule is to be taken empty stomach. How Tasigna Capsule works Tasigna 200mg Capsule is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells. Safety advice 🔹 Primary Use Tasigna is used to treat: ✅ Chronic Myeloid Leukemia (CML) Specifically, Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia. It is used in patients: Who are newly diagnosed with chronic phase CML, or Whose disease has resisted or not responded to previous treatments like imatinib (Gleevec). 🧬 How It Works: Tasigna is a tyrosine kinase inhibitor. It blocks the activity of the BCR-ABL protein, which is produced by the Philadelphia chromosome and causes cancer cells to grow. By blocking this protein, Tasigna helps stop the growth of cancer cells. 📋 Common Dosage Typically: 200 mg taken twice daily, on an empty stomach. Must be taken at least 2 hours after eating and 1 hour before the next meal. 📄 Tasigna 200 mg Capsule – Specification Sheet 🔹 Brand Name: Tasigna 🔹 Generic Name: Nilotinib hydrochloride monohydrate 🔹 Strength: 200 mg per capsule 🔹 Dosage Form: Hard gelatin capsule 🔹 Route of Administration: Oral (by mouth) 🧪 Pharmacological Class: Tyrosine Kinase Inhibitor (TKI) Targets BCR-ABL protein (abnormal tyrosine kinase from the Philadelphia chromosome) 🧪 Pharmacological Class: Tyrosine Kinase Inhibitor (TKI) Targets BCR-ABL protein (abnormal tyrosine kinase from the Philadelphia chromosome) ✅ Indications (Diseases Treated): Philadelphia chromosome-positive Chronic Myeloid Leukemia (Ph+ CML): Chronic Phase (newly diagnosed) Chronic or Accelerated Phase (resistant or intolerant to prior therapy, including imatinib) Typical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it Typical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it Typical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it Typical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it vTypical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it Typical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it 🎯 Main Disease Treated: ✅ Chronic Myeloid Leukemia (CML) A type of blood cancer that affects the white blood cells and the bone marrow. WE EXPORT TO USA WE EXPORT TO UK WE EXPORT TO AUSTRALIA WE EXPORT TO UAE WE EXPORT TO SINGAPORE WE EXPORT TO ITALY WE EXPORT TO CANADA WE ARE A DROPSHIPPER