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'lipid metabolism'

Items tagged with 'lipid metabolism'

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Diabetes & chronic weight management

TIZARO TIRZEPATIDE 12.5mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, EUROPE, UAE Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Tirzepatide is FDA-approved to improve blood sugar (glucose) control in adults with type 2 diabetes, as an adjunct to diet and exercise. It is a once-weekly injectable medication. It works as a dual GIP and GLP-1 receptor agonist, enhancing insulin secretion, reducing glucagon levels, and slowing gastric emptying. It helps lower HbA1c and postprandial glucose levels. Although initially approved for type 2 diabetes, tirzepatide is also being used and studied for weight loss, especially under the brand name Zepbound (approved by the FDA in 2023 for chronic weight management). It is prescribed for people who are: Obese (BMI ≥30), or Overweight (BMI ≥27) with at least one weight-related condition (e.g., hypertension, type 2 diabetes, dyslipidemia). It reduces appetite and calorie intake significantly. 12.5 mg is typically a step-up dose. Patients usually start at a lower dose (e.g., 2.5 mg or 5 mg) and gradually increase every 4 weeks to minimize gastrointestinal side effects. 12.5 mg may be a maintenance or transitional dose toward the maximum dose of 15 mg/week, depending on individual tolerance and treatment goals. Generic Name Tirzepatide Brand Names Mounjaro (for diabetes), Zepbound (for weight loss) Dose Strength 12.5 mg Dosage Form Prefilled pen (subcutaneous injection) Route of Administration Subcutaneous (SC) – once weekly Appearance Clear, colorless to slightly yellow solution TIRZEPATIDE 12.5mg AVAILABLE IN INDIA AT BEST PRICE. https://www.skyblueinternationals.com/ LOOKING FOR GENERIC MEDICINES ??? https://www.skyblueinternationals.com/ TIRZEPATIDE 12.5mg AT LOWEST PRICE TIRZEPATIDE 12.5mg IN STOCK TIRZEPATIDE 12.5mg SHIPPING WORLD WIDE

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Diabetes & chronic weight management

TIZARO TIRZEPATIDE 7.5mg BUY'S IN CANADA, SINGAPORE, AUSTRALIA, USA, EUROPE, UAE Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ DISCRIBTION :- Type 2 Diabetes Mellitus (T2DM) Helps lower blood sugar (HbA1c) effectively Improves insulin sensitivity and secretion Reduces fasting and post-meal glucose spikes ➡️ Often used when 5 mg dose is tolerated well but greater glycemic control is needed. Weight Loss / Obesity Treatment Used for chronic weight management in: Adults with BMI ≥30, or BMI ≥27 with obesity-related conditions (diabetes, hypertension, etc.) At 7.5 mg, patients often report: Stronger appetite suppression Increased fat loss Accelerated body weight reduction vs lower doses ❤️ Cardiometabolic Benefits (Research-based) Helps reduce: LDL cholesterol and triglycerides Blood pressure Systemic inflammation (CRP) 7.5 mg Once weekly (SC injection) Injection sites Abdomen, thigh, upper arm Titration path 2.5 mg → 5 mg → 7.5 mg Max approved dose Up to 15 mg (in some proto How Tizaro Works (Mechanism) GLP-1 action: Enhances insulin release, slows gastric emptying, reduces appetite GIP action: Increases fat metabolism, improves insulin response Together, this dual pathway provides: Superior glucose control Greater weight loss vs other GLP-1 drugs (like semaglutide) BUY FROM US WORLD WIDE SHIPPING WITH GOOD PACKAGING CONTACT US FOR BEST OFFERS & DEALS

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Diabetes & chronic weight management

TIZARO TIRZEPATIDE 2.5mg BUY IN USA, CANADA, SINGAPORE, AUSTRALIA Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Type 2 Diabetes Management TIZARO 2.5mg is used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It enhances insulin secretion and reduces glucagon levels in a glucose-dependent manner. Additionally, it improves insulin sensitivity, aiding in more effective glucose utilization . Weight Management While not officially approved for weight loss, tirzepatide has shown potential in reducing body weight. It may suppress appetite, slow gastric emptying, and increase satiety, which can be beneficial for overweight individuals, particularly those with metabolic disorders Enhancing glucose-dependent insulin secretion Suppressing glucagon Improving insulin sensitivity Delaying gastric emptying to control blood sugar levels Chronic Weight Management Approved for obesity and overweight individuals with comorbidities, due to its: Appetite suppression and increased satiety Slower gastric emptying Significant fat and weight loss demonstrated in clinical trials Cardiovascular & Metabolic Benefits Lowers blood pressure and improves lipid profile Reduces inflammatory markers linked to metabolic syndrome Dosage Details (2.5 mg) Starting dose: 2.5 mg subcutaneous injection once weekly for approximately 4 weeks to minimize GI side effects Administration sites: Abdomen, thigh, or upper arm; consistent day each week BUY NOW FROM US WITH BEST DEALS & OFFERS

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Miscellaneous Peptides

Melanotan-2 10mg, Peptide BUY IN CANADA, SINGAPORE, AUSTRALIA Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪ +917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ ✅ 1. Tanning Agent Primary use: Promotes skin darkening (tanning) by stimulating melanocytes to produce melanin. Users report a deeper, longer-lasting tan with less UV exposure (sunlight or tanning beds). Often used cosmetically to achieve a bronzed look while reducing skin cancer risk from prolonged sun exposure. ✅ 2. Libido Enhancement MT-II stimulates the hypothalamus, increasing libido and erectile function in some users. Studied as a potential treatment for erectile dysfunction (ED), especially where PDE5 inhibitors (like Viagra) are ineffective. ✅ 3. Fat Loss (Anecdotal) Some users report appetite suppression and increased fat metabolism, but scientific evidence is limited. These effects are likely secondary to central nervous system activity. Product Name Melanotan II (Melanotan-2, MT-II) Molecular Weight 1024.18 g/mol Peptide Purity ≥ 98% (HPLC) Appearance White to off-white lyophilized powder A full vial is usually 10mg, reconstituted with bacteriostatic water. Typical research dosing: Start low: 250–500 mcg/day (0.25–0.5mg) subcutaneously. Build up slowly to minimize side effects. Most users don’t exceed 1mg/day. Tanning agent Stimulates melanin for darker skin Libido enhancer Increases arousal and erectile response Appetite suppression May reduce food intake (anecdotal) BUY IN CANADA BUY IN SINGAPORE BUY IN AUSTRALIA BUY IN USA BUY IN ABU DHABI

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Fat Loss & Apoptosis Peptides

Adipotide-FTPP 10mg, Peptide BUY IN SINGAPORE, AUSTRALIA, CANADA Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ 1. Selective Fat Reduction & Body Composition Targets white adipose tissue, causing rapid fat loss without affecting other tissues In mice and obese monkeys, studies showed ~30% body weight loss and ~50% fat mass reduction, while preserving muscle . 2. Metabolic Health & Insulin Sensitivity Improves insulin resistance, glucose tolerance, and lipid profiles in obese animal models. 3. Angiogenesis & Oncology Research Its anti-angiogenic action may also be useful for studying tumor vasculature, as fat and cancer blood vessels share markers. 4. Adipose Tissue Physiology Research Helps assess vascularization, adipogenesis/lipolysis, and adipose-liver or adipose-muscle crosstalk, and may facilitate insights into beige fat activation. Fat-targeting and body composition studies Insulin sensitivity and metabolic pathway analysis Angiogenesis research in adipose and tumor tissues Investigating adipose–organ communication and vascular physiology BUY FAST IN WORLD WIDE

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Sexual & Reproductive Health Peptide

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Generic Name Bremelanotide 1. Hypoactive Sexual Desire Disorder (HSDD) in Women FDA-approved in 2019 under the brand Vyleesi for pre-menopausal women with generalized HSDD unrelated to other medical or psychological condition Improves sexual desire, arousal, and reduces distress linked to low libido 2. Erectile Dysfunction (ED) in Men (Off‑Label) PT‑141 initiates erections via central nervous system pathways, increasing sexual desire and erection quality—even in men unresponsive to PDE‑5 inhibitors Demonstrated increased duration and rigidity of erections in trials 3. Sexual Arousal Support Boosts libido in both genders, addresses low sexual drive and arousal disorders, potentially enhancing orgasm quality and reducing refractory time Bremelanotide is a 7 amino acid peptide used to treat hypoactive sexual desire disorder in premenopausal women. Bremelanotide does not interact with alcohol. The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown. Bremelanotide was first described in the literature in 2003 when it was known by the investigational code PT-141.1 Since then it was investigated for its place in treating sexual dysfunction in men and women but is now only indicated for women.1,2,5 Other drugs used to treat female sexual dysfunction include flibanserin, estrogen, ospemifene, and prasterone. Bremelanotide was granted FDA approval Bremelanotide is an agonist of many melanocortin receptors which in order of potency are MC1R, MC4R, MC3R, MC5R, and MC2R.5 The mechanism by which agonism of these receptors translates to an improvement in hypoactive sexual desire disorder is currently unknown, however MC4R receptors are present in many areas of the central nervous system. MC3R and MC4R are found in the hypothalamus and are involved in food intake and energy homeostasis. Bremelanotide is a 7 amino acid and so its metabolism consists of multiple hydrolysis reactions.

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Healing & Regeneration Peptides

Epithalon (10mg) Peptide Science USE & BENIFITS FAST DELIVERY IN USA Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ 🧠 1. Anti-Aging & Longevity Stimulates telomerase activity, which helps protect DNA by lengthening telomeres — potentially slowing cellular aging. May extend lifespan in animal studies. 🌙 2. Improves Sleep Quality Helps regulate melatonin production via the pineal gland. Used to normalize circadian rhythms in older adults or shift workers. 🧬 3. Supports Cellular Regeneration Encourages healthy cell division and regeneration. May reduce DNA damage associated with aging. 💪 4. Immune System Modulation Boosts T-cell production and immune response in aging individuals. May reduce inflammation and improve resistance to infections. 🧠 5. Neuroprotective Effects Shown in studies to protect neurons and brain function. Possible improvements in mood, memory, and cognitive clarity. ❤️ 6. Cardiovascular & Metabolic Health Potential to reduce oxidative stress and regulate blood pressure. May improve glucose metabolism and reduce risk of age-related diseases. BUY IN TEXAS NEW YORK BUY IN CALIFORNIA BUY IN CHICAGO

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NAD+ & Mitochondrial Support Peptides

Contact Us on telegram or WhatsApp +917887449821‬ +919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ MOTS-c (5mg) :- MOTS-c (5mg), a mitochondrial-derived peptide, is being investigated for its potential to treat metabolic disorders, improve muscle function, and promote healthy aging. It's believed to play a role in regulating energy metabolism, insulin resistance, and the inflammatory response. While research is ongoing, MOTS-c is being explored as a potential therapeutic strategy for conditions like obesity, age-related diseases, and even osteoporosis. MOTS-c stands for 'Mitochondrial Open Reading Frame of the 12S rRNA-c'. It is a 16-amino acid peptide that acts like a hormone, influencing metabolism, stress response, and cellular energy production. Unlike other peptides, it originates from mitochondrial DNA, not nuclear DNA. Exercise and Aging: MOTS-c can enhance exercise endurance and potentially counteract age-related muscle decline Bone Health: Osteoporosis: MOTS-c has been shown to inhibit osteoclast activity and reduce bone loss, suggesting a potential role in preventing and treating osteoporosis. Other Potential Benefits: Anti-inflammatory Effects: MOTS-c may help regulate the inflammatory response, which is implicated in various diseases. Brain Health: Research indicates MOTS-c may improve cognitive function and memory. Cardiovascular Health: MOTS-c has been linked to improved heart function and blood vessel health. 🧠 1. Anti-Aging & Longevity Increases mitochondrial efficiency. Activates AMPK (AMP-activated protein kinase), a key longevity pathway. Promotes cellular stress resistance (e.g., oxidative and metabolic stress). ⚡ 2. Metabolic Health Improves insulin sensitivity and glucose metabolism. Supports weight loss and fat oxidation. Reduces markers of metabolic syndrome and type 2 diabetes in animal models. 💪 3. Exercise & Performance Enhancement Enhances endurance and physical capacity. Protects muscles from exercise-induced stress. Mimics some effects of exercise even without activity ('exercise mimetic'). 🧬 4. Mitochondrial Health Promotes mitochondrial biogenesis. Helps maintain mitochondrial DNA integrity and function under stress. 🧠 5. Neuroprotection (early-stage research) May protect brain cells from oxidative and metabolic damage. MOTS-c (5mg) fast delivery in london

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NAD+ & Mitochondrial Support Peptides

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ SS-31 (25mg) :- SS-31, also known as elamipretide or Bendavia, is a mitochondria-targeting peptide that has shown potential in treating various conditions by improving mitochondrial function. It has been investigated for its antioxidant, anti-inflammatory, and anti-apoptotic properties, particularly in the context of neurodegenerative diseases, inflammatory diseases, and ischemia-reperfusion injury. SS-31 (also known as Elamipretide) is a synthetic peptide that targets and protects mitochondria, the energy-producing structures in cells. The 25 mg dose is commonly used in clinical trials and experimental protocols. Use Details 🫀 Heart Disease Improves heart function in heart failure and ischemic heart disease 🧠 Neurodegenerative Diseases May protect brain cells in conditions like Alzheimer’s, Parkinson’s 👁️ Eye Disorders Studied in dry age-related macular degeneration (dry AMD) 💪 Muscle Fatigue Helps with exercise intolerance and mitochondrial myopathy 🧬 Mitochondrial Dysfunction Repairs damaged mitochondria, boosts ATP production 🧫 Kidney Protection May reduce kidney injury in acute or chronic kidney disease 🧓 Age-Related Fatigue Improves mobility and stamina in older adults How It Works Targets mitochondria directly Binds to cardiolipin in the mitochondrial membrane Prevents oxidative damage Restores energy production (ATP) 💉 Common Dosage Form 25 mg usually administered subcutaneously (under the skin) once daily in studies. SS-31, also known as Elamipretide, is a synthetic peptide designed to improve mitochondrial function and reduce oxidative stress. It's primarily used to protect and restore mitochondrial function, specifically by reducing oxidative stress, stabilizing cardiolipin (a mitochondrial phospholipid), and improving mitochondrial energy production. Research suggests it may also be beneficial in conditions like Alzheimer's, brain injury, and kidney disease. The 25mg dosage refers to the amount of SS-31 in a single dose, often administered via injection. Mitochondrial Target: SS-31 specifically targets mitochondria, the powerhouses of cells, and is thought to protect and restore their function.

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