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Diabetes & chronic weight management

TIZARO TIRZEPATIDE 12.5mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, EUROPE, UAE Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Tirzepatide is FDA-approved to improve blood sugar (glucose) control in adults with type 2 diabetes, as an adjunct to diet and exercise. It is a once-weekly injectable medication. It works as a dual GIP and GLP-1 receptor agonist, enhancing insulin secretion, reducing glucagon levels, and slowing gastric emptying. It helps lower HbA1c and postprandial glucose levels. Although initially approved for type 2 diabetes, tirzepatide is also being used and studied for weight loss, especially under the brand name Zepbound (approved by the FDA in 2023 for chronic weight management). It is prescribed for people who are: Obese (BMI ≥30), or Overweight (BMI ≥27) with at least one weight-related condition (e.g., hypertension, type 2 diabetes, dyslipidemia). It reduces appetite and calorie intake significantly. 12.5 mg is typically a step-up dose. Patients usually start at a lower dose (e.g., 2.5 mg or 5 mg) and gradually increase every 4 weeks to minimize gastrointestinal side effects. 12.5 mg may be a maintenance or transitional dose toward the maximum dose of 15 mg/week, depending on individual tolerance and treatment goals. Generic Name Tirzepatide Brand Names Mounjaro (for diabetes), Zepbound (for weight loss) Dose Strength 12.5 mg Dosage Form Prefilled pen (subcutaneous injection) Route of Administration Subcutaneous (SC) – once weekly Appearance Clear, colorless to slightly yellow solution TIRZEPATIDE 12.5mg AVAILABLE IN INDIA AT BEST PRICE. https://www.skyblueinternationals.com/ LOOKING FOR GENERIC MEDICINES ??? https://www.skyblueinternationals.com/ TIRZEPATIDE 12.5mg AT LOWEST PRICE TIRZEPATIDE 12.5mg IN STOCK TIRZEPATIDE 12.5mg SHIPPING WORLD WIDE

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Diabetes & chronic weight management

TIZARO TIRZEPATIDE 7.5mg BUY'S IN CANADA, SINGAPORE, AUSTRALIA, USA, EUROPE, UAE Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ DISCRIBTION :- Type 2 Diabetes Mellitus (T2DM) Helps lower blood sugar (HbA1c) effectively Improves insulin sensitivity and secretion Reduces fasting and post-meal glucose spikes ➡️ Often used when 5 mg dose is tolerated well but greater glycemic control is needed. Weight Loss / Obesity Treatment Used for chronic weight management in: Adults with BMI ≥30, or BMI ≥27 with obesity-related conditions (diabetes, hypertension, etc.) At 7.5 mg, patients often report: Stronger appetite suppression Increased fat loss Accelerated body weight reduction vs lower doses ❤️ Cardiometabolic Benefits (Research-based) Helps reduce: LDL cholesterol and triglycerides Blood pressure Systemic inflammation (CRP) 7.5 mg Once weekly (SC injection) Injection sites Abdomen, thigh, upper arm Titration path 2.5 mg → 5 mg → 7.5 mg Max approved dose Up to 15 mg (in some proto How Tizaro Works (Mechanism) GLP-1 action: Enhances insulin release, slows gastric emptying, reduces appetite GIP action: Increases fat metabolism, improves insulin response Together, this dual pathway provides: Superior glucose control Greater weight loss vs other GLP-1 drugs (like semaglutide) BUY FROM US WORLD WIDE SHIPPING WITH GOOD PACKAGING CONTACT US FOR BEST OFFERS & DEALS

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Neurological & Cognitive Peptides

FoxO4-DRI 10mg Peptide Science |USES|DOSES| UNITED KINGDOM FAST DELIVERY Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ FoxO4-DRI = A powerful senolytic research peptide Acts via FoxO4-p53 disruption, promoting senescent cell apoptosis Highly promising in aging, neurodegeneration, and regenerative biology fields 🔬 1. Anti-Aging & Longevity Research Clears senescent cells, which accumulate with age and cause inflammation and tissue dysfunction. By removing these cells, FoxO4-DRI may slow biological aging and restore tissue function (based on animal studies). Shown to extend healthspan (not necessarily lifespan) in mice. 🧪 2. Cellular Rejuvenation Helps promote tissue regeneration and stem cell activation. May reverse signs of aging at the cellular level, especially in tissues like muscles, kidneys, and the brain. 🧠 3. Cognitive Health Studies in mice showed memory improvement and neural rejuvenation in aged animals after FoxO4-DRI treatment. Potential use in research for neurodegenerative diseases like Alzheimer’s or age-related cognitive decline. 🩺 4. Senolytic Therapy Research Works by disrupting the interaction between FoxO4 and p53, which causes senescent cells to undergo apoptosis (programmed cell death). May be combined in research with other senolytics like Dasatinib and Quercetin. BUY IN WORLD WIDE BUY IN UK, USA, UAE, SINGAPORE

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Healing & Regeneration Peptides

Epithalon (10mg) Peptide Science USE & BENIFITS FAST DELIVERY IN USA Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ 🧠 1. Anti-Aging & Longevity Stimulates telomerase activity, which helps protect DNA by lengthening telomeres — potentially slowing cellular aging. May extend lifespan in animal studies. 🌙 2. Improves Sleep Quality Helps regulate melatonin production via the pineal gland. Used to normalize circadian rhythms in older adults or shift workers. 🧬 3. Supports Cellular Regeneration Encourages healthy cell division and regeneration. May reduce DNA damage associated with aging. 💪 4. Immune System Modulation Boosts T-cell production and immune response in aging individuals. May reduce inflammation and improve resistance to infections. 🧠 5. Neuroprotective Effects Shown in studies to protect neurons and brain function. Possible improvements in mood, memory, and cognitive clarity. ❤️ 6. Cardiovascular & Metabolic Health Potential to reduce oxidative stress and regulate blood pressure. May improve glucose metabolism and reduce risk of age-related diseases. BUY IN TEXAS NEW YORK BUY IN CALIFORNIA BUY IN CHICAGO

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NAD+ & Mitochondrial Support Peptides

Contact Us on telegram or WhatsApp +917887449821‬ ‪+919168783773‬ +91 9529672584‬ +91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ ✅ NAD⁺ (750 mg) – Uses and Benefits A 750 mg dose of NAD⁺ is considered a high oral dose for supplementation. At this level, it is often used for more targeted therapeutic effects or in anti-aging protocols, and may be part of high-dose oral or IV regimens. NAD⁺ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell that plays a crucial role in: Energy production (mitochondrial ATP synthesis) DNA repair Cell survival and aging Activation of sirtuins (longevity-related enzymes) 🧠 Emerging Research Areas NAD⁺ at this dose is being studied for: Parkinson’s, Alzheimer’s, and cognitive decline Chronic fatigue syndrome (ME/CFS) Immune function in aging (immunosenescence) NAD+ (750mg) improves mitochondrial health and slows the aging process. Neuroprotection (Brain Health): NAD+ (750mg) helps protect the health of your neurons and brain health for better mental clarity now and in the future. Mood Regulation: NAD+ is known to have positive effects on mood and mental well-being.

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Metabolic & Weight Management Peptides

Tirzepatide (60mg) FAST DELIVERY TO FLORIDA Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Tirzepatide (60mg) Uses: Type 2 Diabetes: Tirzepatide is used to improve blood sugar control in adults with type 2 diabetes, often used with diet and exercise. Weight Management: It is also used for weight loss, particularly in adults who are overweight or obese, or who have weight-related medical problems. a synthetic peptide, a dual agonist for both GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide) receptors. It is used to treat type 2 diabetes and may also be used for weight management. It works by mimicking the effects of two hormones involved in glucose regulation and appetite control, helping to lower blood sugar levels and potentially leading to weight loss. Tirzepatide is administered as a once-weekly subcutaneous injection. Dual Action: Tirzepatide targets both GLP-1 and GIP receptors, enhancing insulin sensitivity and potentially leading to weight loss. Mechanism of Action: It increases insulin secretion when blood sugar is high, lowers liver glucose production, and slows down food movement through the digestive tract, contributing to blood sugar control and weight loss. Administration: Tirzepatide is a subcutaneous injection, given once weekly. Potential Side Effects: Common side effects include nausea, vomiting, diarrhea, and constipation, especially during the initial dose escalation phase. Top Benefits of Tirzepatide :- Powerful Blood Sugar Control (Type 2 Diabetes) Lowers HbA1c levels significantly (up to 2.4% reduction) Helps regulate insulin and glucagon more effectively than GLP-1 drugs alone Outperforms other drugs like semaglutide and insulin degludec in trials

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Metabolic & Weight Management Peptides

TO BUY Tirzepatide (40mg) Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com Internationalskyblue@gmail.com Viwe our catalog :- https://wa.me/c/917499402610 Tirzepatide is a dual agonist for the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors. The drug leads to significantly improved glycemic control and weight reduction in patients with T2DM, maximizing benefits similar to GLP-1 medications such as semaglutide. Tirzepatide (Zepbound brand) is used for weight loss, to help lose weight and keep weight off. Tirzepatide works for weight loss by decreasing appetite and slowing the movement of food from the stomach into the small intestine, which may make you feel full more quickly and for a longer period. The Zepbound brand of tirzepatide is also used for moderate to severe obstructive sleep apnea (OSA) in adults with obesity. Tirzepatide is a once-weekly injection given under the skin using a pen (autoinjector). Zepbound (tirzepatide) is FDA-approved for weight loss in adults with obesity or who are overweight and have weight-related medical problems or OSA. Zepbound helps you to lose weight and maintain weight loss and should be combined with diet and exercise. Tirzepatide (Mounjaro brand) is used for type 2 diabetes to help improve blood sugar levels. In type 2 diabetes, tirzepatide decreases blood sugar levels by helping release insulin when blood sugar levels are high, lowering the amount of sugar the liver makes, and slowing food movement through the intestines. Mounjaro should be used together with diet and exercise. Mounjaro (tirzepatide) is FDA-approved to treat adults with type 2 diabetes and should be used together with diet and exercise. It can be used as a single therapy (on its own) or with other diabetes medicines, including sulfonylureas, SGLT2 inhibitors, or metformin. It is not known if tirzepatide can be used in people who have had pancreatitis. Tirzepatide should not be used in people who have type 1 diabetes. Normally, when we eat, natural hormones called GIP and GLP-1 are released by the gut. These hormones increase insulin release, suppress appetite, slow gastric emptying, and increase the feeling of fullness. Tirzepatide works like our natural hormones GIP and GLP-1 by activating the GIP and GLP-1 receptors. Tirzepatide is a GIP and GLP-1 receptor agonist. Tirzepatide works (mechanism of action) by activating both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors. Weight Loss Achieved: tirzepatide: 64.6% of participants lost 15% of their weight semaglutide: 40.1% of participants lost 15% of their weighT Tirzepatide (40mg) USE FOR WEIGHT LOSS Mechanisms: Increases insulin release in response to glucose Reduces glucagon secretion Slows digestion to avoid sugar spikes

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Metabolic & Weight Management Peptides

Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://wa.me/c/917499402610 Name Semaglutide Purity ≥98% (as tested by HPLC, High-Performance Liquid Chromatography) CAS Number 910463-68-2 Molecular Formula C₁₈₇H₂₉₁N₄₅O₅₉ Molecular Weight ~4113.58 g/mol Peptide Sequence Modified GLP-1 (7-37) analog with substitutions to enhance stability Form Lyophilized powder (freeze-dried) Content 3mg per vial Semaglutide is a medication originally developed for type 2 diabetes and obesity treatment. It's a GLP-1 receptor agonist, meaning it mimics the hormone GLP-1, which helps regulate blood sugar and appetite. Type 2 Diabetes Management Lowers blood sugar by increasing insulin release and reducing glucagon secretion. Helps patients achieve better glycemic control. Weight Loss (Obesity or Overweight with Comorbidities) Reduces appetite and slows gastric emptying. FDA-approved under the brand name Wegovy for chronic weight management. 💉 Semaglutide 3mg – Dosing Guide (Research and Clinical Context) ✅ Clinically Approved Dosing (Prescription Use) Under brand names like Ozempic (for diabetes) and Wegovy (for weight loss), the FDA-approved semaglutide dosing follows this gradual titration to minimize side effects: Week Dose (Subcutaneous Injection) Weeks 1–4 0.25 mg once weekly Weeks 5–8 0.5 mg once weekly Weeks 9–12 1.0 mg once weekly (maintenance or increase as needed) Weeks 13+ 1.7 mg – 2.4 mg weekly (Wegovy max) or up to 2.0 mg (Ozempic max) Route: Subcutaneous injection (abdomen, thigh, or upper arm) Frequency: Once per week, same day/time ⚠️ Important Notes Side Effects: Can include nausea, vomiting, diarrhea, abdominal pain, and risk of pancreatitis. Not for Type 1 Diabetes or Ketoacidosis. Only certain brands and dosages are approved for specific uses.

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Metabolic & Weight Management Peptides

Semaglutide 3mg USES Brand Name: Rybelsus Formulation: Oral tablet Dosing: Once daily, taken on an empty stomach with water Type 2 Diabetes Management (Primary Use) Initial dose: 3 mg is used as a starting dose to allow the body to adjust to the medication. It is not therapeutic on its own—patients are usually titrated to 7 mg or 14 mg for full glucose-lowering effect. Helps lower blood sugar (HbA1c) in adults with Type 2 diabetes. How It Works. Semaglutide is a GLP-1 receptor agonist, which: Stimulates insulin secretion (when glucose is high) Reduces glucagon secretion Slows gastric emptying Reduces appetite (mildly at this dose) DOSAGE :- Start at 0.25 mg once weekly. After 4 weeks, increase the dose to 0.5 mg once weekly. If after at least 4 weeks additional glycemic control is needed, increase to 1 mg once weekly (2.1).  Administer once weekly at any time of day, with or without meals  If a dose is missed administer within 5 days of missed dose  Inject subcutaneously in the abdomen, thigh, or upper arm Indications & Uses Initial dose for Type 2 diabetes mellitus treatment (used for 30 days before titration to 7 mg or 14 mg) Helps lower blood glucose (HbA1c) Used in combination with diet and exercise Wegovy (semaglutide) for weight loss Wegovy (semaglutide) is used for weight loss and weight maintenance in patients 12 years and older with obesity Used for reducing major cardiovascular event risks (such as heart attack, stroke, or death) in adults with type 2 diabetes with known heart disease Injection is given 1 time a week under the skin of the stomach (belly), the thigh, or the upper arm, using an autoinjector (pen) This injection should be used in addition to a reduced-calorie diet and increased physical activity

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