The first 29 amino acids of GHRH were discovered to be as equally potent as its full 44 amino acid structure[1][2] This fragment became known as GRF (1-29). However, due to a rapid metabolic clearance analogues of GRF (1-29) were synthesized to enhance the biological activity and reduce the rapidity of metabolic clearance. These analogues were primarily created by substituting amino acids within the peptide structure for amino acids more resistant to enzymatic cleavage. One early analogue substituted the amino acid L-alanine (abbreviated as Ala or A) at the 2nd position of the peptide structure for its optical isomer (mirror image), D-alanine (abbreviated as D-Ala). This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment.[3][4] This successful modification prompted the further creation of analogues with additional amino acid substitutions. Ipamorelin: A selective growth hormone secretagogue, Ipamorelin stimulates the release of GH by mimicking ghrelin's action on the ghrelin receptor. It is known for its specificity and minimal side effects compared to other GH-releasing peptides. Mod GRF 1-29 (CJC-1295 without DAC): This is a modified version of the first 29 amino acids of growth hormone-releasing hormone (GHRH). The modifications extend its half-life and enhance its ability to stimulate the pituitary gland to release GH. It is often used in research to study GH secretion patterns and related metabolic effects. ⚖️ Dosage and Composition The 5/5 mg blend indicates that each vial contains 5 mg of Mod GRF 1-29 and 5 mg of Ipamorelin, totaling 10 mg per vial. This combination is designed to provide a balanced stimulation of GH release, potentially offering synergistic effects when used in research protocols. 🔬 Research Applications In scientific studies, this peptide blend is utilized to: Study Growth Hormone Dynamics: Investigating the patterns and regulation of GH secretion. Metabolic Research: Understanding the role of GH in metabolism, including fat metabolism and muscle growth. Aging and Longevity Studies: Exploring the effects of GH on aging processes and potential therapeutic applications. Sleep and Recovery Research: Examining how GH influences sleep patterns and recovery processes. ⚠️ Important Considerations Research Use Only: These peptides are intended strictly for laboratory research and are not approved for human or veterinary use. Legal Status: The legality of purchasing and possessing these peptides varies by country and jurisdiction. It's essential to consult local regulations before acquiring them. Storage and Handling: Proper storage conditions are crucial to maintain peptide stability. Typically, lyophilized peptides should be stored at -20°C or colder and protected from light. Reconstitution should be done with appropriate solvents, and solutions should be stored at 4°C and used within a specified timeframe. Mod GRF 1-29 + Ipamorelin (5/5 mg) is primarily used in scientific research and clinical studies to investigate its effects on human growth hormone (GH) release and related metabolic functions. It is not FDA-approved for general medical use, but here are the commonly researched uses and potential applications: Stimulation of Growth Hormone (GH) Release Both peptides work synergistically to enhance the natural pulsatile release of GH from the pituitary gland. Mod GRF 1-29 initiates GH release, while Ipamorelin amplifies it by mimicking ghrelin. Anti-Aging Studies GH has regenerative effects on tissues, so researchers study this combo to explore its potential for: Improving skin elasticity Increasing energy levels Enhancing sleep quality Muscle Growth and Recovery (in studies) GH can help stimulate muscle protein synthesis and recovery. This combo is sometimes researched for its effects on lean muscle mass and exercise recovery. Fat Loss & Metabolic Support GH mobilizes stored fat, making this blend of interest in obesity and metabolic syndrome research. May support lipolysis (fat breakdown) in clinical models. Bone Density Studies GH supports bone mineralization. This combo is explored for potential applications in osteopenia/osteoporosis research. Sleep Improvement GH release is tied to deep sleep stages; researchers observe whether this combo improves sleep architecture and REM sleep. Modified GRF (1-29) acts to increase growth hormone production and release by binding to the growth-hormone-releasing hormone receptor (GHRHR) on cells in the anterior pituitary.

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Generic Name Bremelanotide 1. Hypoactive Sexual Desire Disorder (HSDD) in Women FDA-approved in 2019 under the brand Vyleesi for pre-menopausal women with generalized HSDD unrelated to other medical or psychological condition Improves sexual desire, arousal, and reduces distress linked to low libido 2. Erectile Dysfunction (ED) in Men (Off‑Label) PT‑141 initiates erections via central nervous system pathways, increasing sexual desire and erection quality—even in men unresponsive to PDE‑5 inhibitors Demonstrated increased duration and rigidity of erections in trials 3. Sexual Arousal Support Boosts libido in both genders, addresses low sexual drive and arousal disorders, potentially enhancing orgasm quality and reducing refractory time Bremelanotide is a 7 amino acid peptide used to treat hypoactive sexual desire disorder in premenopausal women. Bremelanotide does not interact with alcohol. The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown. Bremelanotide was first described in the literature in 2003 when it was known by the investigational code PT-141.1 Since then it was investigated for its place in treating sexual dysfunction in men and women but is now only indicated for women.1,2,5 Other drugs used to treat female sexual dysfunction include flibanserin, estrogen, ospemifene, and prasterone. Bremelanotide was granted FDA approval Bremelanotide is an agonist of many melanocortin receptors which in order of potency are MC1R, MC4R, MC3R, MC5R, and MC2R.5 The mechanism by which agonism of these receptors translates to an improvement in hypoactive sexual desire disorder is currently unknown, however MC4R receptors are present in many areas of the central nervous system. MC3R and MC4R are found in the hypothalamus and are involved in food intake and energy homeostasis. Bremelanotide is a 7 amino acid and so its metabolism consists of multiple hydrolysis reactions.

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ TB-500 (10mg) It is a first-in-class peptide candidate that promotes the following*: Endothelial (blood vessels) cell differentiation Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues Keratinocyte migration Collagen deposition; and Decreases inflammation. TB-500 (10 mg) is a synthetic version of a naturally occurring peptide called Thymosin Beta-4, specifically designed to support tissue regeneration, healing, and inflammation reduction. It is widely used in sports medicine, biohacking, and research protocols for injury recovery and performance support. Name: TB-500 (Thymosin Beta-4 Acetate, synthetic fragment) Structure: 43 amino acid peptide (active portion of full Thymosin Beta-4) Form: Lyophilized powder, typically in 10 mg vials for ease of multi-dose use TB-500 (10 mg) 🧠 1. Tissue Repair and Regeneration Promotes healing of muscles, tendons, and ligaments Facilitates angiogenesis (formation of new blood vessels) to speed tissue recovery Improves cell migration and differentiation to injury sites 🦴 2. Joint, Ligament & Tendon Recovery Used for chronic joint pain, arthritis, or tendonitis (e.g., elbow, shoulder, knee) Often combined with BPC-157 for synergistic musculoskeletal healing 💪 3. Muscle Recovery and Performance Enhances muscle growth, flexibility, and strength restoration Reduces inflammation and helps repair overtrained or injured muscle tissue 🧬 4. Hair Growth (Experimental) May support hair follicle regeneration and increase hair growth phase duration Sometimes used in off-label protocols for hair loss 🩹 5. Wound Healing Speeds dermal healing of cuts, abrasions, and post-surgical wounds Increases keratinocyte and endothelial cell movement to wound site 💊 Primary Uses of TB-500 (10 mg) 🧠 1. Tissue Repair and Regeneration Promotes healing of muscles, tendons, and ligaments Facilitates angiogenesis (formation of new blood vessels) to speed tissue recovery Improves cell migration and differentiation to injury sites 🦴 2. Joint, Ligament & Tendon Recovery Used for chronic joint pain, arthritis, or tendonitis (e.g., elbow, shoulder, knee) Often combined with BPC-157 for synergistic musculoskeletal healing 💪 3. Muscle Recovery and Performance Enhances muscle growth, flexibility, and strength restoration Reduces inflammation and helps repair overtrained or injured muscle tissue 🧬 4. Hair Growth (Experimental) May support hair follicle regeneration and increase hair growth phase duration Sometimes used in off-label protocols for hair loss 🩹 5. Wound Healing Speeds dermal healing of cuts, abrasions, and post-surgical wounds Increases keratinocyte and endothelial cell movement to wound site BUY IT FROM https://www.skyblueinternationals.com/

Contact Us on telegram or WhatsApp +917887449821‬ +919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ MOTS-c (5mg) :- MOTS-c (5mg), a mitochondrial-derived peptide, is being investigated for its potential to treat metabolic disorders, improve muscle function, and promote healthy aging. It's believed to play a role in regulating energy metabolism, insulin resistance, and the inflammatory response. While research is ongoing, MOTS-c is being explored as a potential therapeutic strategy for conditions like obesity, age-related diseases, and even osteoporosis. MOTS-c stands for 'Mitochondrial Open Reading Frame of the 12S rRNA-c'. It is a 16-amino acid peptide that acts like a hormone, influencing metabolism, stress response, and cellular energy production. Unlike other peptides, it originates from mitochondrial DNA, not nuclear DNA. Exercise and Aging: MOTS-c can enhance exercise endurance and potentially counteract age-related muscle decline Bone Health: Osteoporosis: MOTS-c has been shown to inhibit osteoclast activity and reduce bone loss, suggesting a potential role in preventing and treating osteoporosis. Other Potential Benefits: Anti-inflammatory Effects: MOTS-c may help regulate the inflammatory response, which is implicated in various diseases. Brain Health: Research indicates MOTS-c may improve cognitive function and memory. Cardiovascular Health: MOTS-c has been linked to improved heart function and blood vessel health. 🧠 1. Anti-Aging & Longevity Increases mitochondrial efficiency. Activates AMPK (AMP-activated protein kinase), a key longevity pathway. Promotes cellular stress resistance (e.g., oxidative and metabolic stress). ⚡ 2. Metabolic Health Improves insulin sensitivity and glucose metabolism. Supports weight loss and fat oxidation. Reduces markers of metabolic syndrome and type 2 diabetes in animal models. 💪 3. Exercise & Performance Enhancement Enhances endurance and physical capacity. Protects muscles from exercise-induced stress. Mimics some effects of exercise even without activity ('exercise mimetic'). 🧬 4. Mitochondrial Health Promotes mitochondrial biogenesis. Helps maintain mitochondrial DNA integrity and function under stress. 🧠 5. Neuroprotection (early-stage research) May protect brain cells from oxidative and metabolic damage. MOTS-c (5mg) fast delivery in london

Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://wa.me/c/917499402610 Name Semaglutide Purity ≥98% (as tested by HPLC, High-Performance Liquid Chromatography) CAS Number 910463-68-2 Molecular Formula C₁₈₇H₂₉₁N₄₅O₅₉ Molecular Weight ~4113.58 g/mol Peptide Sequence Modified GLP-1 (7-37) analog with substitutions to enhance stability Form Lyophilized powder (freeze-dried) Content 3mg per vial Semaglutide is a medication originally developed for type 2 diabetes and obesity treatment. It's a GLP-1 receptor agonist, meaning it mimics the hormone GLP-1, which helps regulate blood sugar and appetite. Type 2 Diabetes Management Lowers blood sugar by increasing insulin release and reducing glucagon secretion. Helps patients achieve better glycemic control. Weight Loss (Obesity or Overweight with Comorbidities) Reduces appetite and slows gastric emptying. FDA-approved under the brand name Wegovy for chronic weight management. 💉 Semaglutide 3mg – Dosing Guide (Research and Clinical Context) ✅ Clinically Approved Dosing (Prescription Use) Under brand names like Ozempic (for diabetes) and Wegovy (for weight loss), the FDA-approved semaglutide dosing follows this gradual titration to minimize side effects: Week Dose (Subcutaneous Injection) Weeks 1–4 0.25 mg once weekly Weeks 5–8 0.5 mg once weekly Weeks 9–12 1.0 mg once weekly (maintenance or increase as needed) Weeks 13+ 1.7 mg – 2.4 mg weekly (Wegovy max) or up to 2.0 mg (Ozempic max) Route: Subcutaneous injection (abdomen, thigh, or upper arm) Frequency: Once per week, same day/time ⚠️ Important Notes Side Effects: Can include nausea, vomiting, diarrhea, abdominal pain, and risk of pancreatitis. Not for Type 1 Diabetes or Ketoacidosis. Only certain brands and dosages are approved for specific uses.

Product introduction Tasigna 200mg Capsule is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects. Tasigna 200mg Capsule should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Headache, nausea, abdominal pain, and rash are very common side effects of this medicine. If you experience severe diarrhea, consult with your doctor or drink plenty of fluids while on treatment. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and blood uric acid levels and blood sugar or fat level in the body. Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy. How to use Tasigna Capsule Take this medicine in the dose and duration as advised by your doctor. Tasigna 200mg Capsule is to be taken empty stomach. How Tasigna Capsule works Tasigna 200mg Capsule is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells. Safety advice 🔹 Primary Use Tasigna is used to treat: ✅ Chronic Myeloid Leukemia (CML) Specifically, Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia. It is used in patients: Who are newly diagnosed with chronic phase CML, or Whose disease has resisted or not responded to previous treatments like imatinib (Gleevec). 🧬 How It Works: Tasigna is a tyrosine kinase inhibitor. It blocks the activity of the BCR-ABL protein, which is produced by the Philadelphia chromosome and causes cancer cells to grow. By blocking this protein, Tasigna helps stop the growth of cancer cells. 📋 Common Dosage Typically: 200 mg taken twice daily, on an empty stomach. Must be taken at least 2 hours after eating and 1 hour before the next meal. 📄 Tasigna 200 mg Capsule – Specification Sheet 🔹 Brand Name: Tasigna 🔹 Generic Name: Nilotinib hydrochloride monohydrate 🔹 Strength: 200 mg per capsule 🔹 Dosage Form: Hard gelatin capsule 🔹 Route of Administration: Oral (by mouth) 🧪 Pharmacological Class: Tyrosine Kinase Inhibitor (TKI) Targets BCR-ABL protein (abnormal tyrosine kinase from the Philadelphia chromosome) 🧪 Pharmacological Class: Tyrosine Kinase Inhibitor (TKI) Targets BCR-ABL protein (abnormal tyrosine kinase from the Philadelphia chromosome) ✅ Indications (Diseases Treated): Philadelphia chromosome-positive Chronic Myeloid Leukemia (Ph+ CML): Chronic Phase (newly diagnosed) Chronic or Accelerated Phase (resistant or intolerant to prior therapy, including imatinib) Typical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it Typical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it Typical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it Typical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it vTypical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it Typical adult dose: 200 mg twice daily Must be taken on an empty stomach At least 2 hours after a meal Do not eat for 1 hour after taking it 🎯 Main Disease Treated: ✅ Chronic Myeloid Leukemia (CML) A type of blood cancer that affects the white blood cells and the bone marrow. WE EXPORT TO USA WE EXPORT TO UK WE EXPORT TO AUSTRALIA WE EXPORT TO UAE WE EXPORT TO SINGAPORE WE EXPORT TO ITALY WE EXPORT TO CANADA WE ARE A DROPSHIPPER