age supplementation crucial role proteins involved vital role reduce signs topical formulations detox programs weight management sirtuin activation combat fatigue atp energy redox reactions coenzyme facilitating peptide science 100mg dose potentially mitigate cellular health potentially longevity antiaging supporting neuronal function sirt1 cognitive function maintaining nad levels fundamental cellular processes dna repair nad aging nad plays antiaging products included higher amounts skin ease withdrawal symptoms genomic stability primary enzymes called parps potential therapeutic applications potential benefits related cheapest price contact