'induce apoptosis'

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Generic Name :- Kisspeptin-10 Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins 1. Stimulation of Gonadotropin-Releasing Hormone (GnRH) Kisspeptin-10 stimulates the hypothalamus to release GnRH, which then promotes the secretion of: Luteinizing hormone (LH) Follicle-stimulating hormone (FSH) This cascade is crucial for puberty onset, ovulation, and fertility regulation. 2. Fertility Research Used in assisted reproductive technologies (ART) and IVF studies to promote natural hormonal responses. Can potentially reduce the need for synthetic hormones like hCG. 3. Hypogonadism and Delayed Puberty Investigated as a treatment for hypogonadotropic hypogonadism (low LH/FSH due to low GnRH). May help restore reproductive function in affected individuals. 4. Polycystic Ovary Syndrome (PCOS) Studied for its role in correcting LH/FSH imbalances in PCOS patients. 5. Diagnostic Use Used to test pituitary function or the integrity of the hypothalamic-pituitary-gonadal (HPG) axis. BUY Kisspeptin-10 5mg IN CHEAP PRICE GET BEST OFFERS ON Kisspeptin-10 5mg FROM US SKYBLUE INTERNATIONAL

FoxO4-DRI 10mg Peptide Science |USES|DOSES| UNITED KINGDOM FAST DELIVERY Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ FoxO4-DRI = A powerful senolytic research peptide Acts via FoxO4-p53 disruption, promoting senescent cell apoptosis Highly promising in aging, neurodegeneration, and regenerative biology fields 🔬 1. Anti-Aging & Longevity Research Clears senescent cells, which accumulate with age and cause inflammation and tissue dysfunction. By removing these cells, FoxO4-DRI may slow biological aging and restore tissue function (based on animal studies). Shown to extend healthspan (not necessarily lifespan) in mice. 🧪 2. Cellular Rejuvenation Helps promote tissue regeneration and stem cell activation. May reverse signs of aging at the cellular level, especially in tissues like muscles, kidneys, and the brain. 🧠 3. Cognitive Health Studies in mice showed memory improvement and neural rejuvenation in aged animals after FoxO4-DRI treatment. Potential use in research for neurodegenerative diseases like Alzheimer’s or age-related cognitive decline. 🩺 4. Senolytic Therapy Research Works by disrupting the interaction between FoxO4 and p53, which causes senescent cells to undergo apoptosis (programmed cell death). May be combined in research with other senolytics like Dasatinib and Quercetin. BUY IN WORLD WIDE BUY IN UK, USA, UAE, SINGAPORE

P21 (P021) 5mg Peptide mechanism of Action Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Product Name P21 Peptide (a.k.a. P021) Common Dosage Form 5mg lyophilized powder per vial Type Synthetic neurotrophic peptide Molecular Formula Varies (not publicly disclosed due to proprietary status) Molecular Weight ~1,200–1,800 Da (estimated, depending on modification) CAS Number Not officially registered (research compound) Sequence Proprietary — derived from a CNTF (Ciliary Neurotrophic Factor) analog Purity ≥ 98% (HPLC tested) Peptide Content ≥ 90% Appearance White to off-white lyophilized powder 🧠 Primary Uses of P21 (5mg): 1. Cognitive Enhancement (Nootropic Use) Improves memory, learning speed, and mental clarity Supports executive function and attention span Often used by individuals looking to combat brain fog or age-related decline 2. Neurogenesis & Brain Repair Promotes growth of new neurons (neurogenesis) and synaptic plasticity May help in recovery from brain injury, stroke, or trauma 3. Neuroprotection Reduces oxidative stress, inflammation, and cell death in brain tissues Protects neurons from degenerative conditions like Alzheimer’s or Parkinson’s (in animal models) 4. Mood and Motivation May increase dopaminergic activity, supporting motivation, drive, and emotional balance Anecdotal reports suggest reduced anxiety and depressive symptoms 5. Combating Age-Related Cognitive Decline Potential anti-aging effects on brain structure and function May increase levels of BDNF (Brain-Derived Neurotrophic Factor) ⚙️ Mechanism of Action Mimics and enhances CNTF (Ciliary Neurotrophic Factor) signaling Promotes neural stem cell differentiation Boosts BDNF and NGF (nerve growth factor) activity Inhibits pathways involved in neuronal apoptosis (cell death) buy from us at best price

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ BPC-157 (10mg) BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. BPC-157 (10 mg) is a higher-dose vial of the Body Protective Compound-157, used for the same purposes as the 5 mg version—but typically more convenient for longer cycles, higher doses, or multi-site injuries. 🦴 1. Muscle, Tendon, Ligament, and Joint Repair Speeds healing from injuries: strains, tears, sprains, surgeries Often used by athletes recovering from rotator cuff tears, knee injuries, or Achilles tendonitis Can be injected near the injury or taken systemically 🧠 2. Nerve Healing & Neuroprotection Supports regeneration of damaged peripheral nerves May assist in recovery from nerve crush injuries or neuropathy Early animal studies show neuroprotective effects in traumatic brain injury models 🧪 3. Gastrointestinal Repair One of the most effective peptides for gut healing Used in: Leaky gut IBS / IBD (Crohn’s, ulcerative colitis) Gastric ulcers NSAID-induced intestinal damage 🧘‍♂️ 4. Anti-Inflammatory Effects Reduces chronic systemic inflammation Supports reduction of oxidative stress Can improve pain, swelling, and mobility in injured or inflamed tissues 🔁 5. Wound Healing & Skin Regeneration Applied (sometimes topically or injected near wound) to accelerate healing of: Cuts and abrasions Post-surgical wounds Burns 🏋️‍♂️ 6. Athletic Recovery & Performance Used in biohacking and performance enhancement protocols Shortens recovery time between workouts Helps prevent overuse injuries ⚙️ Why Use a 10 mg Vial? More convenient for: Longer treatment cycles (2–6 weeks) Larger body weight or higher dosing needs Multiple injury sites (e.g., knee + shoulder) Reduces frequency of reconstitution BPC-157 (10mg) IS AVAILABLE

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ BPC-157 (5mg) :- Abstract. BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon. Full Name: Body Protective Compound-157 Source: Derived from a protein found in human gastric juice Molecular Weight: ~1,419 Da Form: Synthetic peptide, usually as a 5 mg lyophilized powder BPC-157 is FDA-approved but is widely studied in animal models and used off-label in sports medicine, biohacking, and functional medicine. 1. 🦴 Tendon, Ligament, and Muscle Healing Accelerates repair of torn tendons and ligaments (e.g. ACL, rotator cuff) Supports muscle regeneration after injury or surgery Enhances collagen synthesis and angiogenesis 2. 🧘‍♂️ Joint & Cartilage Repair Used in cases of arthritis, joint pain, and cartilage degeneration May protect chondrocytes and stimulate cartilage regeneration 3. 🧠 Neurological and Nerve Healing Promotes recovery of damaged peripheral nerves Shown to help in cases of traumatic brain injury (TBI) and nerve crush injuries (animal data) 4. 🧪 Gut Health Extremely effective in healing the GI tract Used for: IBD (Crohn’s, ulcerative colitis) Leaky gut syndrome Gastric ulcers NSAID-induced damage 5. 🔥 Anti-Inflammatory & Cytoprotective Reduces systemic inflammation and oxidative stress Protects cells from toxins, ischemia, and stress damage 6. 💉 Wound Healing & Skin Repair Speeds up recovery of burns, cuts, and abrasions May improve scarring and skin regeneration 7. 💪 Performance & Recovery Used by athletes to speed recovery from training or injury May help mitigate damage from overtraining BUY IT FROM US https://www.skyblueinternationals.com/

Contact Us on telegram or WhatsApp +917887449821‬ +919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ MOTS-c (5mg) :- MOTS-c (5mg), a mitochondrial-derived peptide, is being investigated for its potential to treat metabolic disorders, improve muscle function, and promote healthy aging. It's believed to play a role in regulating energy metabolism, insulin resistance, and the inflammatory response. While research is ongoing, MOTS-c is being explored as a potential therapeutic strategy for conditions like obesity, age-related diseases, and even osteoporosis. MOTS-c stands for 'Mitochondrial Open Reading Frame of the 12S rRNA-c'. It is a 16-amino acid peptide that acts like a hormone, influencing metabolism, stress response, and cellular energy production. Unlike other peptides, it originates from mitochondrial DNA, not nuclear DNA. Exercise and Aging: MOTS-c can enhance exercise endurance and potentially counteract age-related muscle decline Bone Health: Osteoporosis: MOTS-c has been shown to inhibit osteoclast activity and reduce bone loss, suggesting a potential role in preventing and treating osteoporosis. Other Potential Benefits: Anti-inflammatory Effects: MOTS-c may help regulate the inflammatory response, which is implicated in various diseases. Brain Health: Research indicates MOTS-c may improve cognitive function and memory. Cardiovascular Health: MOTS-c has been linked to improved heart function and blood vessel health. 🧠 1. Anti-Aging & Longevity Increases mitochondrial efficiency. Activates AMPK (AMP-activated protein kinase), a key longevity pathway. Promotes cellular stress resistance (e.g., oxidative and metabolic stress). ⚡ 2. Metabolic Health Improves insulin sensitivity and glucose metabolism. Supports weight loss and fat oxidation. Reduces markers of metabolic syndrome and type 2 diabetes in animal models. 💪 3. Exercise & Performance Enhancement Enhances endurance and physical capacity. Protects muscles from exercise-induced stress. Mimics some effects of exercise even without activity ('exercise mimetic'). 🧬 4. Mitochondrial Health Promotes mitochondrial biogenesis. Helps maintain mitochondrial DNA integrity and function under stress. 🧠 5. Neuroprotection (early-stage research) May protect brain cells from oxidative and metabolic damage. MOTS-c (5mg) fast delivery in london

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ AOD9604 5mg retains the bone stimulating properties of human Growth Hormone. AOD9604 indicates that this drug may have a role in the prevention and possible treatment of osteoporosis, through direct action on osteoblasts, the cells which build new bone. AOD 9604 (5mg) is a synthetic peptide derived from the C-terminal fragment of human growth hormone (hGH). It has been studied for its potential benefits in fat metabolism and weight management. ✅ Uses of AOD 9604 Fat Loss and Weight Management AOD 9604 has been shown to stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (the formation of new fat), potentially aiding in fat loss and weight management. Targeted Fat Reduction The peptide may help reduce fat in specific areas, such as the abdominal region, by promoting the breakdown of stored fat. Improved Metabolism AOD 9604 may enhance metabolic rate, leading to increased calorie burning and potentially supporting weight loss efforts. Muscle Preservation Unlike some weight loss methods, AOD 9604 may help preserve lean muscle mass during fat loss, contributing to improved body composition. Bone and Cartilage Repair Some studies suggest that AOD 9604 may have regenerative properties, potentially aiding in the repair of bone and cartilage tissue. Enhanced Exercise Recovery The peptide may support faster recovery from exercise-induced muscle damage, reducing soreness and improving performance. ⚠️ Important Considerations Administration: AOD 9604 is typically administered via subcutaneous injection Dosage: Common dosing ranges from 300–500 mcg per day, depending on individual goals and protocols. Duration: Treatment cycles often last between 4 to 12 weeks, followed by breaks to assess effectiveness and reduce potential side effects. Consultation: It's crucial to consult with a healthcare professional before starting AOD 9604 therapy to ensure it's appropriate for your individual health needs and goals. AOD 9604 peptide therapy is considered a safe and effective solution for weight loss.