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'hypothalamic kiss1kiss1r system'

Items tagged with 'hypothalamic kiss1kiss1r system'

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Sexual & Reproductive Health Peptides

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Generic Name :- Kisspeptin-10 Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins 1. Stimulation of Gonadotropin-Releasing Hormone (GnRH) Kisspeptin-10 stimulates the hypothalamus to release GnRH, which then promotes the secretion of: Luteinizing hormone (LH) Follicle-stimulating hormone (FSH) This cascade is crucial for puberty onset, ovulation, and fertility regulation. 2. Fertility Research Used in assisted reproductive technologies (ART) and IVF studies to promote natural hormonal responses. Can potentially reduce the need for synthetic hormones like hCG. 3. Hypogonadism and Delayed Puberty Investigated as a treatment for hypogonadotropic hypogonadism (low LH/FSH due to low GnRH). May help restore reproductive function in affected individuals. 4. Polycystic Ovary Syndrome (PCOS) Studied for its role in correcting LH/FSH imbalances in PCOS patients. 5. Diagnostic Use Used to test pituitary function or the integrity of the hypothalamic-pituitary-gonadal (HPG) axis. BUY Kisspeptin-10 5mg IN CHEAP PRICE GET BEST OFFERS ON Kisspeptin-10 5mg FROM US SKYBLUE INTERNATIONAL

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Chronic Pain Treatment

PREGABALIN CAPSULES 75mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, EUROPE, UAE Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Nervigesic 75mg Capsule belongs to the anti-epileptic group of medicines and can also be used to treat certain types of seizures (fits) in combination with other medicines. Additionally, it may also be prescribed to treat the symptoms of anxiety disorder if other medicines are not suitable. 1. Neuropathic Pain Treats nerve pain caused by: Diabetes (Diabetic Neuropathy) Spinal cord injury Post-herpetic neuralgia (after shingles) Sciatica Peripheral neuropathy Mechanism: Calms overactive nerves by modulating calcium channels in the nervous system. 2. Fibromyalgia Reduces widespread musculoskeletal pain, fatigue, and sleep problems common in fibromyalgia patients. 3. Epilepsy (Partial-Onset Seizures) Used as adjunct therapy with other anti-epileptic drugs to control focal seizures. 4. Generalized Anxiety Disorder (GAD) (Off-label in some countries) Helps reduce anxiety by acting on brain signaling, similar to benzodiazepines but without the same dependency profile.

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Diabetes & chronic weight management

TIZARO TIRZEPATIDE 7.5mg BUY'S IN CANADA, SINGAPORE, AUSTRALIA, USA, EUROPE, UAE Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ DISCRIBTION :- Type 2 Diabetes Mellitus (T2DM) Helps lower blood sugar (HbA1c) effectively Improves insulin sensitivity and secretion Reduces fasting and post-meal glucose spikes ➡️ Often used when 5 mg dose is tolerated well but greater glycemic control is needed. Weight Loss / Obesity Treatment Used for chronic weight management in: Adults with BMI ≥30, or BMI ≥27 with obesity-related conditions (diabetes, hypertension, etc.) At 7.5 mg, patients often report: Stronger appetite suppression Increased fat loss Accelerated body weight reduction vs lower doses ❤️ Cardiometabolic Benefits (Research-based) Helps reduce: LDL cholesterol and triglycerides Blood pressure Systemic inflammation (CRP) 7.5 mg Once weekly (SC injection) Injection sites Abdomen, thigh, upper arm Titration path 2.5 mg → 5 mg → 7.5 mg Max approved dose Up to 15 mg (in some proto How Tizaro Works (Mechanism) GLP-1 action: Enhances insulin release, slows gastric emptying, reduces appetite GIP action: Increases fat metabolism, improves insulin response Together, this dual pathway provides: Superior glucose control Greater weight loss vs other GLP-1 drugs (like semaglutide) BUY FROM US WORLD WIDE SHIPPING WITH GOOD PACKAGING CONTACT US FOR BEST OFFERS & DEALS

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Miscellaneous Peptides

Prostamax 20mg, Peptide BUY IN USA, CANADA, SINGAPORE, AUSTRALIA Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪+919529672584‬ ‪ +917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Prostate Health & BPH support Designed to improve prostate function, reduce enlargement (BPH), and ease urinary symptoms (frequent urination, weak stream) It supports prostate cell regeneration, improves urine flow, and helps alleviate conditions like prostatitis Anti-inflammatory action in prostate tissue Exhibits localized anti-inflammatory effects in models of prostatitis and BPH Chromatin modulation & cellular reparative effects Alters DNA/chromatin structure — increasing chromatin accessibility, gene expression, and markers of DNA activity in prostate and lymphocyte cultures. Anti-aging / epigenetic influences Acts as an “anti-aging” peptide with epigenetic/regulatory effects, potentially applicable beyond prostate tissue. Mechanism of Action :- Sequence: Lys‑Glu‑Asp‑Pro (KEDP), molecular weight ~487 g/mol Chromatin remodeling: Promotes decondensation of heterochromatin, elevates sister chromatid exchange and rRNA gene activity — enabling DNA repair and expression Tissue regeneration: In vitro and animal models show reduced swelling, immune infiltration, and tissue scarring in prostate Dosage & Administration Common protocols: ~500–750 µg/day for 2–4 weeks via subcutaneous injection . Aspect Details Peptide Sequence Lys‑Glu‑Asp‑Pro (KEDP) Target Areas Prostate tissue, urinary system, lymphocytes Key Actions Anti-inflammatory, tissue repair, chromatin remodeling Dose Range ~500–750 µg/day via sub‑Q injection Typical Course 2–4 weeks, sometimes repeated after break Status Research only — not for clinical use BUY IN CANADA BUY IN SINGAPORE BUY IN AUSTRALIA BUY IN USA BUY IN ABU DHABI

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Miscellaneous Peptides

Melanotan-2 10mg, Peptide BUY IN CANADA, SINGAPORE, AUSTRALIA Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪ +917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ ✅ 1. Tanning Agent Primary use: Promotes skin darkening (tanning) by stimulating melanocytes to produce melanin. Users report a deeper, longer-lasting tan with less UV exposure (sunlight or tanning beds). Often used cosmetically to achieve a bronzed look while reducing skin cancer risk from prolonged sun exposure. ✅ 2. Libido Enhancement MT-II stimulates the hypothalamus, increasing libido and erectile function in some users. Studied as a potential treatment for erectile dysfunction (ED), especially where PDE5 inhibitors (like Viagra) are ineffective. ✅ 3. Fat Loss (Anecdotal) Some users report appetite suppression and increased fat metabolism, but scientific evidence is limited. These effects are likely secondary to central nervous system activity. Product Name Melanotan II (Melanotan-2, MT-II) Molecular Weight 1024.18 g/mol Peptide Purity ≥ 98% (HPLC) Appearance White to off-white lyophilized powder A full vial is usually 10mg, reconstituted with bacteriostatic water. Typical research dosing: Start low: 250–500 mcg/day (0.25–0.5mg) subcutaneously. Build up slowly to minimize side effects. Most users don’t exceed 1mg/day. Tanning agent Stimulates melanin for darker skin Libido enhancer Increases arousal and erectile response Appetite suppression May reduce food intake (anecdotal) BUY IN CANADA BUY IN SINGAPORE BUY IN AUSTRALIA BUY IN USA BUY IN ABU DHABI

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Neurological & Cognitive Peptides

Semax 30mg Peptide uses & doses USA fast delivery Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ 🧠 Primary Uses of Semax (30mg): 1. Cognitive Enhancement (Nootropic Use) Improves memory, focus, mental clarity, and learning ability Enhances executive function and creativity Often used by students, professionals, and biohackers 2. Neuroprotection Protects neurons from oxidative stress and damage Used in Russia after strokes, traumatic brain injuries, or brain surgeries 3. Mood and Stress Regulation Reduces symptoms of depression, anxiety, and mental fatigue Regulates stress by modulating the adrenal response and dopamine system 4. Treatment for ADHD & Cognitive Disorders Can support focus and impulse control in individuals with ADHD Sometimes used off-label to enhance dopaminergic transmission 5. Improved Recovery After Neurological Events Clinically used in post-stroke therapy in Russia Enhances cerebral blood flow and helps with neurological rehabilitation 6. Immune System Modulation May boost immune system response and inflammatory regulation Form Typical Dose Route Frequency 30mg vial (powder) 200–600 mcg per dose Intranasal (most common) 1–3 times per day

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Neurological & Cognitive Peptides

PEPTIDE Selank 10mg FAST DELIVERY in LONDON Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ USES :- Anxiety Reduction (Anxiolytic Effect) Acts on GABA receptors (like benzodiazepines but without sedation or addiction risk) Reduces symptoms of: Generalized anxiety Social anxiety Stress and tension Cognitive Enhancement (Nootropic) Improves: Focus Mental clarity Memory retention and recall Used for cognitive fatigue and brain fog Improves Mood & Emotional Stability Regulates serotonin and dopamine levels in the brain May help with mild depression and mood swings Immune System Modulation Enhances immune system balance without overstimulation Originally developed in Russia for treating immune-related conditions and infections Neuroprotection Protects neurons from oxidative stress and damage May support recovery after traumatic brain injury or chronic stress

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Healing & Regeneration Peptides

Epithalon (10mg) Peptide Science USE & BENIFITS FAST DELIVERY IN USA Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ 🧠 1. Anti-Aging & Longevity Stimulates telomerase activity, which helps protect DNA by lengthening telomeres — potentially slowing cellular aging. May extend lifespan in animal studies. 🌙 2. Improves Sleep Quality Helps regulate melatonin production via the pineal gland. Used to normalize circadian rhythms in older adults or shift workers. 🧬 3. Supports Cellular Regeneration Encourages healthy cell division and regeneration. May reduce DNA damage associated with aging. 💪 4. Immune System Modulation Boosts T-cell production and immune response in aging individuals. May reduce inflammation and improve resistance to infections. 🧠 5. Neuroprotective Effects Shown in studies to protect neurons and brain function. Possible improvements in mood, memory, and cognitive clarity. ❤️ 6. Cardiovascular & Metabolic Health Potential to reduce oxidative stress and regulate blood pressure. May improve glucose metabolism and reduce risk of age-related diseases. BUY IN TEXAS NEW YORK BUY IN CALIFORNIA BUY IN CHICAGO

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Healing & Regeneration Peptides

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ BPC-157 (10mg) BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. BPC-157 (10 mg) is a higher-dose vial of the Body Protective Compound-157, used for the same purposes as the 5 mg version—but typically more convenient for longer cycles, higher doses, or multi-site injuries. 🦴 1. Muscle, Tendon, Ligament, and Joint Repair Speeds healing from injuries: strains, tears, sprains, surgeries Often used by athletes recovering from rotator cuff tears, knee injuries, or Achilles tendonitis Can be injected near the injury or taken systemically 🧠 2. Nerve Healing & Neuroprotection Supports regeneration of damaged peripheral nerves May assist in recovery from nerve crush injuries or neuropathy Early animal studies show neuroprotective effects in traumatic brain injury models 🧪 3. Gastrointestinal Repair One of the most effective peptides for gut healing Used in: Leaky gut IBS / IBD (Crohn’s, ulcerative colitis) Gastric ulcers NSAID-induced intestinal damage 🧘‍♂️ 4. Anti-Inflammatory Effects Reduces chronic systemic inflammation Supports reduction of oxidative stress Can improve pain, swelling, and mobility in injured or inflamed tissues 🔁 5. Wound Healing & Skin Regeneration Applied (sometimes topically or injected near wound) to accelerate healing of: Cuts and abrasions Post-surgical wounds Burns 🏋️‍♂️ 6. Athletic Recovery & Performance Used in biohacking and performance enhancement protocols Shortens recovery time between workouts Helps prevent overuse injuries ⚙️ Why Use a 10 mg Vial? More convenient for: Longer treatment cycles (2–6 weeks) Larger body weight or higher dosing needs Multiple injury sites (e.g., knee + shoulder) Reduces frequency of reconstitution BPC-157 (10mg) IS AVAILABLE

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