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'affecting tumorigenicity'

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Sexual & Reproductive Health Peptides

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Generic Name :- Kisspeptin-10 Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins 1. Stimulation of Gonadotropin-Releasing Hormone (GnRH) Kisspeptin-10 stimulates the hypothalamus to release GnRH, which then promotes the secretion of: Luteinizing hormone (LH) Follicle-stimulating hormone (FSH) This cascade is crucial for puberty onset, ovulation, and fertility regulation. 2. Fertility Research Used in assisted reproductive technologies (ART) and IVF studies to promote natural hormonal responses. Can potentially reduce the need for synthetic hormones like hCG. 3. Hypogonadism and Delayed Puberty Investigated as a treatment for hypogonadotropic hypogonadism (low LH/FSH due to low GnRH). May help restore reproductive function in affected individuals. 4. Polycystic Ovary Syndrome (PCOS) Studied for its role in correcting LH/FSH imbalances in PCOS patients. 5. Diagnostic Use Used to test pituitary function or the integrity of the hypothalamic-pituitary-gonadal (HPG) axis. BUY Kisspeptin-10 5mg IN CHEAP PRICE GET BEST OFFERS ON Kisspeptin-10 5mg FROM US SKYBLUE INTERNATIONAL

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Erectile Dysfunction Medicines

Sildenafil Citrate CENFORCE 50mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, UK, EUROPE, UAE & GET 20% OFF ON BULK ORDER Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.medicinesfromindia.com/ Cenforce 50 mg which contains Sildenafil Citrate used for erectile dysfunction treatment. Cenforce 50mg Tablet is a phosphodiesterase (PDE-5) inhibitor. Cenforce, comparatively, claims a similar onset and duration of action, offering a generic alternative. Benefits of Cenforce It works by relaxing the blood vessels in your penis. Cenforce 50mg (Sildenafil Citrate Tablets) used both get and maintain an erection by affecting the response to sexual compunction. Sildenafil citrate acts by enhancing smooth muscle relaxation. This smooth muscle relaxation allows increased blood flow into accurate areas of the penis, leading to an erection. Cenforce 50mg is a medication used to treat erectile dysfunction (ED) in men. It contains sildenafil citrate, the same active ingredient found in Viagra. Mechanism of Action :- Sildenafil (a PDE5 inhibitor) blocks the enzyme phosphodiesterase type 5, which enhances the effects of nitric oxide, a chemical that relaxes muscles in the penis and increases blood flow. It does not cause an erection on its own—sexual arousal is required. BUY NOW TO GET BEST OFFERS & DEALS

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Erectile Dysfunction Medicines

Sildenafil Citrate CENFORCE 25mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, UK, EUROPE, UAE & GET 10% OFF ON BULK ORDER Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.medicinesfromindia.com/ Cenforce 25mg (Sildenafil Citrate Tablets) used both get and maintain an erection by affecting the response to sexual compunction. Sildenafil citrate acts by enhancing smooth muscle relaxation. This smooth muscle relaxation allows increased blood flow into accurate areas of the penis, leading to an erection. Cenforce 25 mg is a medication used to treat erectile dysfunction (ED) in men. It contains sildenafil citrate, the same active ingredient found in Viagra. Mechanism of Action :- Sildenafil (a PDE5 inhibitor) blocks the enzyme phosphodiesterase type 5, which enhances the effects of nitric oxide, a chemical that relaxes muscles in the penis and increases blood flow. It does not cause an erection on its own—sexual arousal is required. BUY NOW TO GET BEST OFFERS & DEALS

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Fat Loss & Apoptosis Peptides

Adipotide-FTPP 10mg, Peptide BUY IN SINGAPORE, AUSTRALIA, CANADA Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ 1. Selective Fat Reduction & Body Composition Targets white adipose tissue, causing rapid fat loss without affecting other tissues In mice and obese monkeys, studies showed ~30% body weight loss and ~50% fat mass reduction, while preserving muscle . 2. Metabolic Health & Insulin Sensitivity Improves insulin resistance, glucose tolerance, and lipid profiles in obese animal models. 3. Angiogenesis & Oncology Research Its anti-angiogenic action may also be useful for studying tumor vasculature, as fat and cancer blood vessels share markers. 4. Adipose Tissue Physiology Research Helps assess vascularization, adipogenesis/lipolysis, and adipose-liver or adipose-muscle crosstalk, and may facilitate insights into beige fat activation. Fat-targeting and body composition studies Insulin sensitivity and metabolic pathway analysis Angiogenesis research in adipose and tumor tissues Investigating adipose–organ communication and vascular physiology BUY FAST IN WORLD WIDE

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