Brand name: PREMARIN® Generic name: Conjugated estrogens Dosage form: Vaginal cream Strength: 0.625 mg conjugated estrogens per gram (commonly available strength) Route of administration: Vaginal (local application) Composition Each gram of cream contains: Conjugated estrogens 0.625 mg Cream base and approved excipients Drug Class Estrogen hormone Hormone replacement therapy (HRT) Mechanism of Action Replaces estrogen locally in vaginal tissues Improves thickness, elasticity, and lubrication of vaginal lining Indications Atrophic vaginitis Vulvar and vaginal atrophy due to estrogen deficiency Menopausal vaginal symptoms (dryness, irritation, burning) Uses of PREMARIN Cream It is mainly used in women with low estrogen levels Common medical uses Relief of vaginal symptoms due to estrogen deficiency, such as: Vaginal dryness Burning or itching Pain during urination Discomfort during intercourse Atrophic vaginitis (thinning and inflammation of vaginal tissues) Vulvar and vaginal atrophy caused by menopause or medical estrogen deficiency How it works (simple explanation) Replaces estrogen locally in vaginal tissues Helps restore moisture, thickness, and elasticity Reduces irritation and discomfort