The first 29 amino acids of GHRH were discovered to be as equally potent as its full 44 amino acid structure[1][2] This fragment became known as GRF (1-29). However, due to a rapid metabolic clearance analogues of GRF (1-29) were synthesized to enhance the biological activity and reduce the rapidity of metabolic clearance. These analogues were primarily created by substituting amino acids within the peptide structure for amino acids more resistant to enzymatic cleavage. One early analogue substituted the amino acid L-alanine (abbreviated as Ala or A) at the 2nd position of the peptide structure for its optical isomer (mirror image), D-alanine (abbreviated as D-Ala). This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment.[3][4] This successful modification prompted the further creation of analogues with additional amino acid substitutions. Ipamorelin: A selective growth hormone secretagogue, Ipamorelin stimulates the release of GH by mimicking ghrelin's action on the ghrelin receptor. It is known for its specificity and minimal side effects compared to other GH-releasing peptides. Mod GRF 1-29 (CJC-1295 without DAC): This is a modified version of the first 29 amino acids of growth hormone-releasing hormone (GHRH). The modifications extend its half-life and enhance its ability to stimulate the pituitary gland to release GH. It is often used in research to study GH secretion patterns and related metabolic effects. ⚖️ Dosage and Composition The 5/5 mg blend indicates that each vial contains 5 mg of Mod GRF 1-29 and 5 mg of Ipamorelin, totaling 10 mg per vial. This combination is designed to provide a balanced stimulation of GH release, potentially offering synergistic effects when used in research protocols. 🔬 Research Applications In scientific studies, this peptide blend is utilized to: Study Growth Hormone Dynamics: Investigating the patterns and regulation of GH secretion. Metabolic Research: Understanding the role of GH in metabolism, including fat metabolism and muscle growth. Aging and Longevity Studies: Exploring the effects of GH on aging processes and potential therapeutic applications. Sleep and Recovery Research: Examining how GH influences sleep patterns and recovery processes. ⚠️ Important Considerations Research Use Only: These peptides are intended strictly for laboratory research and are not approved for human or veterinary use. Legal Status: The legality of purchasing and possessing these peptides varies by country and jurisdiction. It's essential to consult local regulations before acquiring them. Storage and Handling: Proper storage conditions are crucial to maintain peptide stability. Typically, lyophilized peptides should be stored at -20°C or colder and protected from light. Reconstitution should be done with appropriate solvents, and solutions should be stored at 4°C and used within a specified timeframe. Mod GRF 1-29 + Ipamorelin (5/5 mg) is primarily used in scientific research and clinical studies to investigate its effects on human growth hormone (GH) release and related metabolic functions. It is not FDA-approved for general medical use, but here are the commonly researched uses and potential applications: Stimulation of Growth Hormone (GH) Release Both peptides work synergistically to enhance the natural pulsatile release of GH from the pituitary gland. Mod GRF 1-29 initiates GH release, while Ipamorelin amplifies it by mimicking ghrelin. Anti-Aging Studies GH has regenerative effects on tissues, so researchers study this combo to explore its potential for: Improving skin elasticity Increasing energy levels Enhancing sleep quality Muscle Growth and Recovery (in studies) GH can help stimulate muscle protein synthesis and recovery. This combo is sometimes researched for its effects on lean muscle mass and exercise recovery. Fat Loss & Metabolic Support GH mobilizes stored fat, making this blend of interest in obesity and metabolic syndrome research. May support lipolysis (fat breakdown) in clinical models. Bone Density Studies GH supports bone mineralization. This combo is explored for potential applications in osteopenia/osteoporosis research. Sleep Improvement GH release is tied to deep sleep stages; researchers observe whether this combo improves sleep architecture and REM sleep. Modified GRF (1-29) acts to increase growth hormone production and release by binding to the growth-hormone-releasing hormone receptor (GHRHR) on cells in the anterior pituitary.

P21 (P021) 5mg Peptide mechanism of Action Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Product Name P21 Peptide (a.k.a. P021) Common Dosage Form 5mg lyophilized powder per vial Type Synthetic neurotrophic peptide Molecular Formula Varies (not publicly disclosed due to proprietary status) Molecular Weight ~1,200–1,800 Da (estimated, depending on modification) CAS Number Not officially registered (research compound) Sequence Proprietary — derived from a CNTF (Ciliary Neurotrophic Factor) analog Purity ≥ 98% (HPLC tested) Peptide Content ≥ 90% Appearance White to off-white lyophilized powder 🧠 Primary Uses of P21 (5mg): 1. Cognitive Enhancement (Nootropic Use) Improves memory, learning speed, and mental clarity Supports executive function and attention span Often used by individuals looking to combat brain fog or age-related decline 2. Neurogenesis & Brain Repair Promotes growth of new neurons (neurogenesis) and synaptic plasticity May help in recovery from brain injury, stroke, or trauma 3. Neuroprotection Reduces oxidative stress, inflammation, and cell death in brain tissues Protects neurons from degenerative conditions like Alzheimer’s or Parkinson’s (in animal models) 4. Mood and Motivation May increase dopaminergic activity, supporting motivation, drive, and emotional balance Anecdotal reports suggest reduced anxiety and depressive symptoms 5. Combating Age-Related Cognitive Decline Potential anti-aging effects on brain structure and function May increase levels of BDNF (Brain-Derived Neurotrophic Factor) ⚙️ Mechanism of Action Mimics and enhances CNTF (Ciliary Neurotrophic Factor) signaling Promotes neural stem cell differentiation Boosts BDNF and NGF (nerve growth factor) activity Inhibits pathways involved in neuronal apoptosis (cell death) buy from us at best price

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ TB-500 (10mg) It is a first-in-class peptide candidate that promotes the following*: Endothelial (blood vessels) cell differentiation Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues Keratinocyte migration Collagen deposition; and Decreases inflammation. TB-500 (10 mg) is a synthetic version of a naturally occurring peptide called Thymosin Beta-4, specifically designed to support tissue regeneration, healing, and inflammation reduction. It is widely used in sports medicine, biohacking, and research protocols for injury recovery and performance support. Name: TB-500 (Thymosin Beta-4 Acetate, synthetic fragment) Structure: 43 amino acid peptide (active portion of full Thymosin Beta-4) Form: Lyophilized powder, typically in 10 mg vials for ease of multi-dose use TB-500 (10 mg) 🧠 1. Tissue Repair and Regeneration Promotes healing of muscles, tendons, and ligaments Facilitates angiogenesis (formation of new blood vessels) to speed tissue recovery Improves cell migration and differentiation to injury sites 🦴 2. Joint, Ligament & Tendon Recovery Used for chronic joint pain, arthritis, or tendonitis (e.g., elbow, shoulder, knee) Often combined with BPC-157 for synergistic musculoskeletal healing 💪 3. Muscle Recovery and Performance Enhances muscle growth, flexibility, and strength restoration Reduces inflammation and helps repair overtrained or injured muscle tissue 🧬 4. Hair Growth (Experimental) May support hair follicle regeneration and increase hair growth phase duration Sometimes used in off-label protocols for hair loss 🩹 5. Wound Healing Speeds dermal healing of cuts, abrasions, and post-surgical wounds Increases keratinocyte and endothelial cell movement to wound site 💊 Primary Uses of TB-500 (10 mg) 🧠 1. Tissue Repair and Regeneration Promotes healing of muscles, tendons, and ligaments Facilitates angiogenesis (formation of new blood vessels) to speed tissue recovery Improves cell migration and differentiation to injury sites 🦴 2. Joint, Ligament & Tendon Recovery Used for chronic joint pain, arthritis, or tendonitis (e.g., elbow, shoulder, knee) Often combined with BPC-157 for synergistic musculoskeletal healing 💪 3. Muscle Recovery and Performance Enhances muscle growth, flexibility, and strength restoration Reduces inflammation and helps repair overtrained or injured muscle tissue 🧬 4. Hair Growth (Experimental) May support hair follicle regeneration and increase hair growth phase duration Sometimes used in off-label protocols for hair loss 🩹 5. Wound Healing Speeds dermal healing of cuts, abrasions, and post-surgical wounds Increases keratinocyte and endothelial cell movement to wound site BUY IT FROM https://www.skyblueinternationals.com/

Semorelin (15mg) UK FAST DELIVERY Sermorelin is used to diagnose and treat poor growth in children. It's also sometimes used off-label to treat hGH deficiency in adults. Some research has suggested that it can be beneficial in people with certain recurrent brain tumors. Children usually benefit the most from sermorelin. Sermorelin is a peptide hormone that is structurally similar to growth hormone-releasing hormone (GHRH). positive effects of sermorelin : Antidepressants like sertraline help to improve your mood so you feel better Popular among aging men and women to mimic youthful GH secretion. Administration: Nighttime injection to mimic natural GH pulses. Does Tesamorelin burn fat? Tesamorelin injection is not used to help with weight loss. Who can't take sermorelin? if you are pregnant, planning to become pregnant, or are breast-feeding. Drug Name Sermorelin Acetate Form Lyophilized powder (freeze-dried) for reconstitution Reconstitution Solvent Bacteriostatic Water for Injection (BWFI) or Sterile Water for Injection Dosing and Administration (Typical) Dose: Varies by provider and goal, but commonly 0.2–0.5 mg/day, subcutaneously at bedtime. 15 mg vial: Typically used over a 30-day period after being reconstituted with bacteriostatic water. Administration: Nighttime injection to mimic natural GH pulses. Improved body composition (more lean mass, less fat) Better sleep Enhanced recovery and energy Possible cognitive and mood improvements

Tesamorelin + CJC-1295 + Ipamorelin (6/3/3mg) FAST DELIVERY TO DOORSTEPS CJC-1295 is an incredibly effective peptide which works by stimulating the release of your own body's growth hormones (which drop quickly after the age of 30). Research has shown that CJC-1295 can increase growth hormone levels by 200-1000% and the elevated growth hormone production continued for up to 6 days. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Powder for Solution. Conclusion: Treatment with tesamorelin was generally well tolerated and resulted in sustained decreases in VAT and triglycerides over 52 weeks without aggravating glucose. Though effects on VAT are sustained during treatment for 52 weeks, these effects do not last beyond the duration of treatment. Signs of high blood sugar like confusion, feeling sleepy, unusual thirst or hunger, passing urine more often, flushing, fast breathing, or breath that smells like fruit. A fast heartbeat. Dizziness or passing out. Flushing. 1. Primary Medical & Performance Uses A. Fat Loss (Especially Visceral Fat) ✅ Tesamorelin (6mg): FDA-approved for HIV lipodystrophy (reduces abdominal fat). Targets stubborn belly fat even in non-HIV patients. ✅ CJC-1295 (3mg) + Ipamorelin (3mg): Amplifies growth hormone (GH) pulses for enhanced fat metabolism. Preserves muscle during calorie deficits. B. Muscle Growth & Recovery Boosts IGF-1 levels → Increases protein synthesis. Accelerates repair of tendons/ligaments (ideal for athletes). C. Anti-Aging & Longevity Improves skin elasticity (collagen stimulation). Enhances sleep quality (GH promotes deep sleep cycles). May support cognitive function (neuroprotective effects). D. Metabolic Health Improves insulin sensitivity (beneficial for prediabetes/metabolic syndrome). Lowers triglycerides (cardiovascular support). 2. Mechanism of Action Peptide Target Effect Tesamorelin GHRH Receptor (Pituitary) Stimulates GH release, specifically reduces visceral fat. CJC-1295 GHRH Receptor (Pituitary) Long-acting GH release (elevates IGF-1 for days). Ipamorelin Ghrelin Receptor Selective GH boost (no cortisol/prolactin spikes). Synergy: Tesamorelin targets fat stores, while CJC-1295 + Ipamorelin prolong GH benefits for muscle and recovery. 3. Dosage & Administration Standard Protocol Blend Ratio: 6mg Tesamorelin + 3mg CJC-1295 + 3mg Ipamorelin per vial. Daily Dose: Tesamorelin: 1–2mg/day (e.g., 1mg AM, 1mg PM). CJC-1295 + Ipamorelin: 100–300mcg each, 1–2x/day (post-workout or bedtime). Cycle Length: 8–12 weeks (followed by 4-week break). Reconstitution Mix with 2–3mL bacteriostatic water (for precise dosing). Storage: Refrigerate after reconstitution (stable for 4–6 weeks). 4. Expected Results & Timeline 📌 Weeks 1–4: Reduced bloating, improved sleep, increased energy. 📌 Weeks 4–8: Visible fat loss (especially abdomen), faster workout recovery. 📌 Weeks 8–12: Lean muscle definition, tighter skin, enhanced endurance. (Optimal with strength training + low-sugar diet.) Final Verdict ✅ Best for: Men/women targeting stubborn belly fat. Athletes wanting muscle preservation + recovery. Anti-aging (skin, cognition, longevity). Description Tesamorelin injection is a hormone similar to the one normally released from the hypothalamus gland in the brain. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Description Tesamorelin injection is a hormone similar to the one normally released from the hypothalamus gland in the brain. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tesamorelin may sometimes be given at home to patients who do not need to be in a hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine. Tesamorelin injection comes with a patient information leaflet and patient instructions. Read the instructions and make sure you understand: How to prepare the injection. Proper use of disposable syringes. How to give the injection. How long the injection is stable. WE EXPORTY TO USA WE EXPORT TO UK WE EXPORT LO CANADA WE EXORT TO AUSTRALIA WE EXPORT ITALY WE EXPORT TO SINGAPORE

Tesamorelin injection is a hormone similar to the one normally released from the hypothalamus gland in the brain. It is used to reduce excess fat (lipodystrophy) in the stomach area in patients with human immunodeficiency virus (HIV) infection. Tesamorelin + Ipamorelin (6mg/2mg) Blend: Medical Uses & Applications This peptide combination is primarily used for metabolic, anti-aging, and body composition benefits. Here’s a breakdown of its primary medical and off-label uses: 1. Approved Medical Use (FDA-Approved for HIV Lipodystrophy) ✅ Tesamorelin (6mg) FDA-approved to treat HIV-associated lipodystrophy (excess belly fat caused by antiretroviral therapy). Mechanism: Stimulates growth hormone (GH) release, reducing visceral fat. 2. Off-Label & Research-Based Uses A. Fat Loss & Metabolic Health Visceral fat reduction (even in non-HIV patients). Improves insulin sensitivity (potential for metabolic syndrome/type 2 diabetes support). B. Muscle Growth & Recovery Ipamorelin (2mg) is a growth hormone secretagogue (GHS) that: Boosts lean muscle mass. Enhances post-workout recovery. C. Anti-Aging & Longevity Increases collagen production (improves skin elasticity). May support cognitive function (GH plays a role in brain health). D. Injury & Tissue Repair Accelerates healing of tendons/ligaments (used by athletes). 3. Typical Treatment Protocol Dosage: Tesamorelin: 1-2mg/day (often 6mg total per week). Ipamorelin: 200-300mcg/day (2mg total per week). Administration: Subcutaneous injections (stomach or thigh). Cycle Length: 8-12 weeks (with breaks to avoid GH desensitization). 4. Key Benefits vs. Other Peptides Peptide Primary Use Pros Cons Tesamorelin FDA-approved fat loss Targets stubborn belly fat Expensive, requires prescri Final Verdict This blend is best for: ✔ Men/women targeting stubborn fat (especially abdominal). ✔ Athletes seeking muscle recovery & anti-aging benefits. ✔ Those wanting a safer alternative to synthetic GH. 4. Typical Dosage & Protocol Tesamorelin: 1-2mg/day (or 6mg/week). Ipamorelin: 200-300mcg/day (or 2mg/week). Administration: Subcutaneous injection (stomach/thigh). Cycle Length: 8-12 weeks (followed by a break to avoid GH resistance). 3. How It Works Tesamorelin → Stimulates pituitary GH release → Reduces visceral fat. 5. Expected Results & Timeline 📌 4-6 Weeks: Reduced belly fat, improved energy. 📌 8-12 Weeks: Visible muscle definition, better skin elasticity. 📌 Beyond 3 Months: Enhanced recovery, potential cognitive benefits. 5. Expected Results & Timeline 📌 4-6 Weeks: Reduced belly fat, improved energy. 📌 8-12 Weeks: Visible muscle definition, better skin elasticity. 📌 Beyond 3 Months: Enhanced recovery, potential cognitive benefits. 5. Expected Results & Timeline 📌 4-6 Weeks: Reduced belly fat, improved energy. 📌 8-12 Weeks: Visible muscle definition, better skin elasticity. 📌 Beyond 3 Months: Enhanced recovery, potential cognitive benefits. (Best when combined with diet + exercise) . Rare (serious): Increased blood sugar (caution for diabetics). Carpal tunnel syndrome (high doses). Final Verdict ✅ Best for: Men/women struggling with belly fat. Athletes seeking muscle recovery + anti-aging. Those wanting GH benefits without synthetic HGH risks. ❌ Not for: Quick fixes – requires consistent use for 2-3 months Tesamorelin, known for reducing abdominal fat in HIV patients with lipodystrophy, together with Ipamorelin, a growth hormone-releasing peptide, can enhance overall body composition improvements. Furthermore, both substances may work synergistically to boost muscle growth, fat loss, recovery, and anti-aging effects, maximizing the benefits of each peptide when used in tandem. Before taking this medicine You should not use tesamorelin if you are allergic to it, or if you have: cancer; a pituitary gland disorder; a history of pituitary gland tumor or surgery; a history of head injury or radiation treatment; or if you are pregnant. To make sure you can safely take tesamorelin, tell your doctor if you have any of these other conditions: a history of cancer or any tumor (either benign or malignant); heart disease, high blood pressure; kidney disease; diabetes, eye problems caused by diabetes; epilepsy asthma; migraine headaches; adrenal gland disorder; if you have ever had open heart surgery; or if you have any major illness, a recent trauma, or a medical emergency. FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use tesamorelin if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. WE EXPORT IN USA WE EXPORT IN UK WE EXPORT IN AUSTRALIA WE EXPORT IN CANADA WE EXPORT IN SINGAPORE

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