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'preclinical studies investigated'

Items tagged with 'preclinical studies investigated'

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Miscellaneous Peptides

Bronchogen 20mg, Peptide BUY IN CANADA, SINGAPORE, AUSTRALIA Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪+919529672584‬ ‪ +917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Peptide-Based Lung Support Acts as a bioregulator, targeting lung tissue at the cellular level—enhancing DNA stability, reducing inflammation, and promoting epithelial repair and surfactant production in preclinical studies Investigated for potential in chronic respiratory conditions like COPD, asthma, and bronchitis—reducing mucus, bronchospasm, and coughing Anti-Inflammatory & Anti-Aging May stabilize DNA, reduce inflammatory cytokines, and support healthy lung function—promising for age-related lung decline Immunomodulation Proposed to support immune function in the lungs, reducing exacerbations in smokers and older individuals Bronchogen 20 mg is a promising experimental peptide aimed at improving lung structure and function. While early data—both preclinical and anecdotal—suggest benefits for inflammation and airflow, it remains unapproved and under-researched. If you're exploring respiratory support, consult a medical professional and consider established therapies (e.g., bronchodilators, inhaled steroids). WORLD WIDE SHIPPING SHIPPING TO YOUR DOOR STEPS

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Sexual & Reproductive Health Peptides

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Generic Name :- Kisspeptin-10 Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins 1. Stimulation of Gonadotropin-Releasing Hormone (GnRH) Kisspeptin-10 stimulates the hypothalamus to release GnRH, which then promotes the secretion of: Luteinizing hormone (LH) Follicle-stimulating hormone (FSH) This cascade is crucial for puberty onset, ovulation, and fertility regulation. 2. Fertility Research Used in assisted reproductive technologies (ART) and IVF studies to promote natural hormonal responses. Can potentially reduce the need for synthetic hormones like hCG. 3. Hypogonadism and Delayed Puberty Investigated as a treatment for hypogonadotropic hypogonadism (low LH/FSH due to low GnRH). May help restore reproductive function in affected individuals. 4. Polycystic Ovary Syndrome (PCOS) Studied for its role in correcting LH/FSH imbalances in PCOS patients. 5. Diagnostic Use Used to test pituitary function or the integrity of the hypothalamic-pituitary-gonadal (HPG) axis. BUY Kisspeptin-10 5mg IN CHEAP PRICE GET BEST OFFERS ON Kisspeptin-10 5mg FROM US SKYBLUE INTERNATIONAL

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NAD+ & Mitochondrial Support Peptides

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ SS-31 (25mg) :- SS-31, also known as elamipretide or Bendavia, is a mitochondria-targeting peptide that has shown potential in treating various conditions by improving mitochondrial function. It has been investigated for its antioxidant, anti-inflammatory, and anti-apoptotic properties, particularly in the context of neurodegenerative diseases, inflammatory diseases, and ischemia-reperfusion injury. SS-31 (also known as Elamipretide) is a synthetic peptide that targets and protects mitochondria, the energy-producing structures in cells. The 25 mg dose is commonly used in clinical trials and experimental protocols. Use Details 🫀 Heart Disease Improves heart function in heart failure and ischemic heart disease 🧠 Neurodegenerative Diseases May protect brain cells in conditions like Alzheimer’s, Parkinson’s 👁️ Eye Disorders Studied in dry age-related macular degeneration (dry AMD) 💪 Muscle Fatigue Helps with exercise intolerance and mitochondrial myopathy 🧬 Mitochondrial Dysfunction Repairs damaged mitochondria, boosts ATP production 🧫 Kidney Protection May reduce kidney injury in acute or chronic kidney disease 🧓 Age-Related Fatigue Improves mobility and stamina in older adults How It Works Targets mitochondria directly Binds to cardiolipin in the mitochondrial membrane Prevents oxidative damage Restores energy production (ATP) 💉 Common Dosage Form 25 mg usually administered subcutaneously (under the skin) once daily in studies. SS-31, also known as Elamipretide, is a synthetic peptide designed to improve mitochondrial function and reduce oxidative stress. It's primarily used to protect and restore mitochondrial function, specifically by reducing oxidative stress, stabilizing cardiolipin (a mitochondrial phospholipid), and improving mitochondrial energy production. Research suggests it may also be beneficial in conditions like Alzheimer's, brain injury, and kidney disease. The 25mg dosage refers to the amount of SS-31 in a single dose, often administered via injection. Mitochondrial Target: SS-31 specifically targets mitochondria, the powerhouses of cells, and is thought to protect and restore their function.

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Fat Loss & Apoptosis Peptides

Adipotide-FTPP 10mg, Peptide BUY IN SINGAPORE, AUSTRALIA, CANADA Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ 1. Selective Fat Reduction & Body Composition Targets white adipose tissue, causing rapid fat loss without affecting other tissues In mice and obese monkeys, studies showed ~30% body weight loss and ~50% fat mass reduction, while preserving muscle . 2. Metabolic Health & Insulin Sensitivity Improves insulin resistance, glucose tolerance, and lipid profiles in obese animal models. 3. Angiogenesis & Oncology Research Its anti-angiogenic action may also be useful for studying tumor vasculature, as fat and cancer blood vessels share markers. 4. Adipose Tissue Physiology Research Helps assess vascularization, adipogenesis/lipolysis, and adipose-liver or adipose-muscle crosstalk, and may facilitate insights into beige fat activation. Fat-targeting and body composition studies Insulin sensitivity and metabolic pathway analysis Angiogenesis research in adipose and tumor tissues Investigating adipose–organ communication and vascular physiology BUY FAST IN WORLD WIDE

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Sexual & Reproductive Health Peptides

Gonadorelin 10mg , Peptide USA FAST DELIVERY Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ 1. 🎯 Diagnostic Testing of the HPG Axis Used to assess pituitary function by measuring LH/FSH response—helpful in diagnosing hypogonadism or pituitary disorders . 2. 👩‍🔬 Female Infertility & Ovulation Induction Triggers ovulation in women with irregular periods Widely used in IVF and ART, often combined with hCG, to improve ovarian response and implantation rates 3. 👨 Male Hypogonadism & Delayed Puberty Stimulates testosterone and spermatogenesis in male hypogonadotropic hypogonadism and delayed puberty Helps prevent testicular atrophy during TRT and promotes natural LH/FSH production 4. 🧬 Hormone-Sensitive Cancers (Experimental) Explored in breast and prostate cancer to suppress estrogen/testosterone over long-term use . 5. 🦴 Bone, Muscle & Metabolic Health (Research) Preliminary studies show benefits for bone density, muscle strength, mood, and metabolic function via hormone regulation . 6. 🧠 Neurological & Cognitive Research Emerging research on GnRH analogues for potential applications in Alzheimer's disease and cognitive health Diagnosing HPG axis function Boosting fertility and managing reproductive disorders Treating male hormonal deficiencies and puberty delay Evaluating emerging roles in cancer, veterinary fertility, bone/muscle health, and neurology FAST DELIVERY FOR USA FAST DELIVERY FOR UK FAST DELIVERY FOR CANADA FAST DELIVERY FOR AUSTRALIA FAST DELIVERY FOR ABU DHABI FAST DELIVERY FOR SINGAPORE

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Sexual & Reproductive Health Peptide

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Generic Name Bremelanotide 1. Hypoactive Sexual Desire Disorder (HSDD) in Women FDA-approved in 2019 under the brand Vyleesi for pre-menopausal women with generalized HSDD unrelated to other medical or psychological condition Improves sexual desire, arousal, and reduces distress linked to low libido 2. Erectile Dysfunction (ED) in Men (Off‑Label) PT‑141 initiates erections via central nervous system pathways, increasing sexual desire and erection quality—even in men unresponsive to PDE‑5 inhibitors Demonstrated increased duration and rigidity of erections in trials 3. Sexual Arousal Support Boosts libido in both genders, addresses low sexual drive and arousal disorders, potentially enhancing orgasm quality and reducing refractory time Bremelanotide is a 7 amino acid peptide used to treat hypoactive sexual desire disorder in premenopausal women. Bremelanotide does not interact with alcohol. The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown. Bremelanotide was first described in the literature in 2003 when it was known by the investigational code PT-141.1 Since then it was investigated for its place in treating sexual dysfunction in men and women but is now only indicated for women.1,2,5 Other drugs used to treat female sexual dysfunction include flibanserin, estrogen, ospemifene, and prasterone. Bremelanotide was granted FDA approval Bremelanotide is an agonist of many melanocortin receptors which in order of potency are MC1R, MC4R, MC3R, MC5R, and MC2R.5 The mechanism by which agonism of these receptors translates to an improvement in hypoactive sexual desire disorder is currently unknown, however MC4R receptors are present in many areas of the central nervous system. MC3R and MC4R are found in the hypothalamus and are involved in food intake and energy homeostasis. Bremelanotide is a 7 amino acid and so its metabolism consists of multiple hydrolysis reactions.

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Neurological & Cognitive Peptides

FoxO4-DRI 10mg Peptide Science |USES|DOSES| UNITED KINGDOM FAST DELIVERY Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ FoxO4-DRI = A powerful senolytic research peptide Acts via FoxO4-p53 disruption, promoting senescent cell apoptosis Highly promising in aging, neurodegeneration, and regenerative biology fields 🔬 1. Anti-Aging & Longevity Research Clears senescent cells, which accumulate with age and cause inflammation and tissue dysfunction. By removing these cells, FoxO4-DRI may slow biological aging and restore tissue function (based on animal studies). Shown to extend healthspan (not necessarily lifespan) in mice. 🧪 2. Cellular Rejuvenation Helps promote tissue regeneration and stem cell activation. May reverse signs of aging at the cellular level, especially in tissues like muscles, kidneys, and the brain. 🧠 3. Cognitive Health Studies in mice showed memory improvement and neural rejuvenation in aged animals after FoxO4-DRI treatment. Potential use in research for neurodegenerative diseases like Alzheimer’s or age-related cognitive decline. 🩺 4. Senolytic Therapy Research Works by disrupting the interaction between FoxO4 and p53, which causes senescent cells to undergo apoptosis (programmed cell death). May be combined in research with other senolytics like Dasatinib and Quercetin. BUY IN WORLD WIDE BUY IN UK, USA, UAE, SINGAPORE

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Healing & Regeneration Peptides

Epithalon (10mg) Peptide Science USE & BENIFITS FAST DELIVERY IN USA Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ 🧠 1. Anti-Aging & Longevity Stimulates telomerase activity, which helps protect DNA by lengthening telomeres — potentially slowing cellular aging. May extend lifespan in animal studies. 🌙 2. Improves Sleep Quality Helps regulate melatonin production via the pineal gland. Used to normalize circadian rhythms in older adults or shift workers. 🧬 3. Supports Cellular Regeneration Encourages healthy cell division and regeneration. May reduce DNA damage associated with aging. 💪 4. Immune System Modulation Boosts T-cell production and immune response in aging individuals. May reduce inflammation and improve resistance to infections. 🧠 5. Neuroprotective Effects Shown in studies to protect neurons and brain function. Possible improvements in mood, memory, and cognitive clarity. ❤️ 6. Cardiovascular & Metabolic Health Potential to reduce oxidative stress and regulate blood pressure. May improve glucose metabolism and reduce risk of age-related diseases. BUY IN TEXAS NEW YORK BUY IN CALIFORNIA BUY IN CHICAGO

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Healing & Regeneration Peptides

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ BPC-157 (10mg) BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. BPC-157 (10 mg) is a higher-dose vial of the Body Protective Compound-157, used for the same purposes as the 5 mg version—but typically more convenient for longer cycles, higher doses, or multi-site injuries. 🦴 1. Muscle, Tendon, Ligament, and Joint Repair Speeds healing from injuries: strains, tears, sprains, surgeries Often used by athletes recovering from rotator cuff tears, knee injuries, or Achilles tendonitis Can be injected near the injury or taken systemically 🧠 2. Nerve Healing & Neuroprotection Supports regeneration of damaged peripheral nerves May assist in recovery from nerve crush injuries or neuropathy Early animal studies show neuroprotective effects in traumatic brain injury models 🧪 3. Gastrointestinal Repair One of the most effective peptides for gut healing Used in: Leaky gut IBS / IBD (Crohn’s, ulcerative colitis) Gastric ulcers NSAID-induced intestinal damage 🧘‍♂️ 4. Anti-Inflammatory Effects Reduces chronic systemic inflammation Supports reduction of oxidative stress Can improve pain, swelling, and mobility in injured or inflamed tissues 🔁 5. Wound Healing & Skin Regeneration Applied (sometimes topically or injected near wound) to accelerate healing of: Cuts and abrasions Post-surgical wounds Burns 🏋️‍♂️ 6. Athletic Recovery & Performance Used in biohacking and performance enhancement protocols Shortens recovery time between workouts Helps prevent overuse injuries ⚙️ Why Use a 10 mg Vial? More convenient for: Longer treatment cycles (2–6 weeks) Larger body weight or higher dosing needs Multiple injury sites (e.g., knee + shoulder) Reduces frequency of reconstitution BPC-157 (10mg) IS AVAILABLE

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