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'early analogue substituted'

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Growth Hormone Secretagogues

The first 29 amino acids of GHRH were discovered to be as equally potent as its full 44 amino acid structure[1][2] This fragment became known as GRF (1-29). However, due to a rapid metabolic clearance analogues of GRF (1-29) were synthesized to enhance the biological activity and reduce the rapidity of metabolic clearance. These analogues were primarily created by substituting amino acids within the peptide structure for amino acids more resistant to enzymatic cleavage. One early analogue substituted the amino acid L-alanine (abbreviated as Ala or A) at the 2nd position of the peptide structure for its optical isomer (mirror image), D-alanine (abbreviated as D-Ala). This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment.[3][4] This successful modification prompted the further creation of analogues with additional amino acid substitutions. Ipamorelin: A selective growth hormone secretagogue, Ipamorelin stimulates the release of GH by mimicking ghrelin's action on the ghrelin receptor. It is known for its specificity and minimal side effects compared to other GH-releasing peptides. Mod GRF 1-29 (CJC-1295 without DAC): This is a modified version of the first 29 amino acids of growth hormone-releasing hormone (GHRH). The modifications extend its half-life and enhance its ability to stimulate the pituitary gland to release GH. It is often used in research to study GH secretion patterns and related metabolic effects. ⚖️ Dosage and Composition The 5/5 mg blend indicates that each vial contains 5 mg of Mod GRF 1-29 and 5 mg of Ipamorelin, totaling 10 mg per vial. This combination is designed to provide a balanced stimulation of GH release, potentially offering synergistic effects when used in research protocols. 🔬 Research Applications In scientific studies, this peptide blend is utilized to: Study Growth Hormone Dynamics: Investigating the patterns and regulation of GH secretion. Metabolic Research: Understanding the role of GH in metabolism, including fat metabolism and muscle growth. Aging and Longevity Studies: Exploring the effects of GH on aging processes and potential therapeutic applications. Sleep and Recovery Research: Examining how GH influences sleep patterns and recovery processes. ⚠️ Important Considerations Research Use Only: These peptides are intended strictly for laboratory research and are not approved for human or veterinary use. Legal Status: The legality of purchasing and possessing these peptides varies by country and jurisdiction. It's essential to consult local regulations before acquiring them. Storage and Handling: Proper storage conditions are crucial to maintain peptide stability. Typically, lyophilized peptides should be stored at -20°C or colder and protected from light. Reconstitution should be done with appropriate solvents, and solutions should be stored at 4°C and used within a specified timeframe. Mod GRF 1-29 + Ipamorelin (5/5 mg) is primarily used in scientific research and clinical studies to investigate its effects on human growth hormone (GH) release and related metabolic functions. It is not FDA-approved for general medical use, but here are the commonly researched uses and potential applications: Stimulation of Growth Hormone (GH) Release Both peptides work synergistically to enhance the natural pulsatile release of GH from the pituitary gland. Mod GRF 1-29 initiates GH release, while Ipamorelin amplifies it by mimicking ghrelin. Anti-Aging Studies GH has regenerative effects on tissues, so researchers study this combo to explore its potential for: Improving skin elasticity Increasing energy levels Enhancing sleep quality Muscle Growth and Recovery (in studies) GH can help stimulate muscle protein synthesis and recovery. This combo is sometimes researched for its effects on lean muscle mass and exercise recovery. Fat Loss & Metabolic Support GH mobilizes stored fat, making this blend of interest in obesity and metabolic syndrome research. May support lipolysis (fat breakdown) in clinical models. Bone Density Studies GH supports bone mineralization. This combo is explored for potential applications in osteopenia/osteoporosis research. Sleep Improvement GH release is tied to deep sleep stages; researchers observe whether this combo improves sleep architecture and REM sleep. Modified GRF (1-29) acts to increase growth hormone production and release by binding to the growth-hormone-releasing hormone receptor (GHRHR) on cells in the anterior pituitary.

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Diabetes & chronic weight management

TIZARO TIRZEPATIDE 10mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, EUROPE, UAE Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Brand Name: TIZARO' prominently printed. Strength: 10 mg clearly stated. Composition: Tirzepatide listed. Manufacturer :- ZISKA PHARMA Description Tizaro is a once weekly antihyperglycemic medication. Tizaro contains an active substance called Tirzepatide is used to treat adults with type 2 diabetes mellitus. Tizaro 10 mg is a higher-dose injectable form of tirzepatide, a dual GIP + GLP-1 receptor agonist Type 2 Diabetes Mellitus Chronic Weight Management (Obesity) Approved use to improve blood sugar control Reduces both fasting and post-meal glucose levels Lowers HbA1c by up to 2.4% in clinical trials Used in combination with: Metformin SGLT2 inhibitors Basal insulin (if required) Approved for adults with: BMI ≥30 (obese), or BMI ≥27 (overweight) with other conditions (diabetes, hypertension, etc.) Stronger appetite suppression More rapid fat burning and weight reduction Average weight loss of 15–22% over several months (as seen in SURMOUNT trials) BUY IT NOW IN USA BUY IT NOW IN UNITED KINGDOM BUY IT NOW IN AUSTRALIA BUY IT NOW IN EUROPE

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Miscellaneous Peptides

Bronchogen 20mg, Peptide BUY IN CANADA, SINGAPORE, AUSTRALIA Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪+919529672584‬ ‪ +917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Peptide-Based Lung Support Acts as a bioregulator, targeting lung tissue at the cellular level—enhancing DNA stability, reducing inflammation, and promoting epithelial repair and surfactant production in preclinical studies Investigated for potential in chronic respiratory conditions like COPD, asthma, and bronchitis—reducing mucus, bronchospasm, and coughing Anti-Inflammatory & Anti-Aging May stabilize DNA, reduce inflammatory cytokines, and support healthy lung function—promising for age-related lung decline Immunomodulation Proposed to support immune function in the lungs, reducing exacerbations in smokers and older individuals Bronchogen 20 mg is a promising experimental peptide aimed at improving lung structure and function. While early data—both preclinical and anecdotal—suggest benefits for inflammation and airflow, it remains unapproved and under-researched. If you're exploring respiratory support, consult a medical professional and consider established therapies (e.g., bronchodilators, inhaled steroids). WORLD WIDE SHIPPING SHIPPING TO YOUR DOOR STEPS

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Sexual & Reproductive Health Peptides

Gonadorelin 10mg , Peptide USA FAST DELIVERY Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ 1. 🎯 Diagnostic Testing of the HPG Axis Used to assess pituitary function by measuring LH/FSH response—helpful in diagnosing hypogonadism or pituitary disorders . 2. 👩‍🔬 Female Infertility & Ovulation Induction Triggers ovulation in women with irregular periods Widely used in IVF and ART, often combined with hCG, to improve ovarian response and implantation rates 3. 👨 Male Hypogonadism & Delayed Puberty Stimulates testosterone and spermatogenesis in male hypogonadotropic hypogonadism and delayed puberty Helps prevent testicular atrophy during TRT and promotes natural LH/FSH production 4. 🧬 Hormone-Sensitive Cancers (Experimental) Explored in breast and prostate cancer to suppress estrogen/testosterone over long-term use . 5. 🦴 Bone, Muscle & Metabolic Health (Research) Preliminary studies show benefits for bone density, muscle strength, mood, and metabolic function via hormone regulation . 6. 🧠 Neurological & Cognitive Research Emerging research on GnRH analogues for potential applications in Alzheimer's disease and cognitive health Diagnosing HPG axis function Boosting fertility and managing reproductive disorders Treating male hormonal deficiencies and puberty delay Evaluating emerging roles in cancer, veterinary fertility, bone/muscle health, and neurology FAST DELIVERY FOR USA FAST DELIVERY FOR UK FAST DELIVERY FOR CANADA FAST DELIVERY FOR AUSTRALIA FAST DELIVERY FOR ABU DHABI FAST DELIVERY FOR SINGAPORE

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Healing & Regeneration Peptides

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ BPC-157 (10mg) BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. BPC-157 (10 mg) is a higher-dose vial of the Body Protective Compound-157, used for the same purposes as the 5 mg version—but typically more convenient for longer cycles, higher doses, or multi-site injuries. 🦴 1. Muscle, Tendon, Ligament, and Joint Repair Speeds healing from injuries: strains, tears, sprains, surgeries Often used by athletes recovering from rotator cuff tears, knee injuries, or Achilles tendonitis Can be injected near the injury or taken systemically 🧠 2. Nerve Healing & Neuroprotection Supports regeneration of damaged peripheral nerves May assist in recovery from nerve crush injuries or neuropathy Early animal studies show neuroprotective effects in traumatic brain injury models 🧪 3. Gastrointestinal Repair One of the most effective peptides for gut healing Used in: Leaky gut IBS / IBD (Crohn’s, ulcerative colitis) Gastric ulcers NSAID-induced intestinal damage 🧘‍♂️ 4. Anti-Inflammatory Effects Reduces chronic systemic inflammation Supports reduction of oxidative stress Can improve pain, swelling, and mobility in injured or inflamed tissues 🔁 5. Wound Healing & Skin Regeneration Applied (sometimes topically or injected near wound) to accelerate healing of: Cuts and abrasions Post-surgical wounds Burns 🏋️‍♂️ 6. Athletic Recovery & Performance Used in biohacking and performance enhancement protocols Shortens recovery time between workouts Helps prevent overuse injuries ⚙️ Why Use a 10 mg Vial? More convenient for: Longer treatment cycles (2–6 weeks) Larger body weight or higher dosing needs Multiple injury sites (e.g., knee + shoulder) Reduces frequency of reconstitution BPC-157 (10mg) IS AVAILABLE

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NAD+ & Mitochondrial Support Peptides

Contact Us on telegram or WhatsApp +917887449821‬ +919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ MOTS-c (5mg) :- MOTS-c (5mg), a mitochondrial-derived peptide, is being investigated for its potential to treat metabolic disorders, improve muscle function, and promote healthy aging. It's believed to play a role in regulating energy metabolism, insulin resistance, and the inflammatory response. While research is ongoing, MOTS-c is being explored as a potential therapeutic strategy for conditions like obesity, age-related diseases, and even osteoporosis. MOTS-c stands for 'Mitochondrial Open Reading Frame of the 12S rRNA-c'. It is a 16-amino acid peptide that acts like a hormone, influencing metabolism, stress response, and cellular energy production. Unlike other peptides, it originates from mitochondrial DNA, not nuclear DNA. Exercise and Aging: MOTS-c can enhance exercise endurance and potentially counteract age-related muscle decline Bone Health: Osteoporosis: MOTS-c has been shown to inhibit osteoclast activity and reduce bone loss, suggesting a potential role in preventing and treating osteoporosis. Other Potential Benefits: Anti-inflammatory Effects: MOTS-c may help regulate the inflammatory response, which is implicated in various diseases. Brain Health: Research indicates MOTS-c may improve cognitive function and memory. Cardiovascular Health: MOTS-c has been linked to improved heart function and blood vessel health. 🧠 1. Anti-Aging & Longevity Increases mitochondrial efficiency. Activates AMPK (AMP-activated protein kinase), a key longevity pathway. Promotes cellular stress resistance (e.g., oxidative and metabolic stress). ⚡ 2. Metabolic Health Improves insulin sensitivity and glucose metabolism. Supports weight loss and fat oxidation. Reduces markers of metabolic syndrome and type 2 diabetes in animal models. 💪 3. Exercise & Performance Enhancement Enhances endurance and physical capacity. Protects muscles from exercise-induced stress. Mimics some effects of exercise even without activity ('exercise mimetic'). 🧬 4. Mitochondrial Health Promotes mitochondrial biogenesis. Helps maintain mitochondrial DNA integrity and function under stress. 🧠 5. Neuroprotection (early-stage research) May protect brain cells from oxidative and metabolic damage. MOTS-c (5mg) fast delivery in london

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NAD+ & Mitochondrial Support Peptides

Contact Us on telegram or WhatsApp +917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ NAD+ (1000mg) NAD+ (1000mg) is often used to address age-related decline in energy levels, cognitive function, and overall vitality. It's also explored for its potential benefits in athletic performance, addiction recovery, and even in mitigating some aspects of neurodegenerative diseases. 🔋 Cellular Energy Production Boosts ATP synthesis in mitochondria. Reduces chronic fatigue and improves physical stamina. Often used by athletes or people with low energy disorders. Anti-Aging & Longevity Activates sirtuins (SIRT1–SIRT7), which: Promote DNA repair Improve mitochondrial health Extend cell lifespan NAD⁺ levels naturally decline with age; high doses help restore youthful levels. Cognitive Enhancement & Brain Health Supports neuroplasticity, memory, and focus. May help in early-stage neurodegenerative conditions like Alzheimer’s or Parkinson’s (as part of a broader protocol). Protects neurons from oxidative stress and inflammation. Addiction Recovery & Detox Support Used in IV NAD⁺ therapy clinics (usually 1000–3000 mg IV per session) to: Reduce withdrawal symptoms from alcohol, opioids, stimulants Improve mental clarity during recovery Oral NAD⁺ (1000 mg) may complement recovery efforts when IV isn't available. Energy and Metabolism: NAD+ is essential for cellular energy production, particularly in the mitochondria. Boosting NAD+ levels can improve energy production, leading to increased stamina and reduced fatigue. This can be beneficial for individuals experiencing age-related energy decline or those seeking to enhance athletic performance. BUY IT FROM US https://www.skyblueinternationals.com/

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Growth Hormone Secretagogues

CJC-1295 + Hexarelin (5/5mg) FAST DELIVERY TO USA This peptide combination includes CJC-1295 (without DAC) and Hexarelin, two potent growth hormone-releasing agents that work synergistically to boost GH levels, enhance muscle growth, accelerate fat loss, and support recovery. to improve health and well-being in aging adults and those who desire better fitness results. Increased Muscle Mass: Enhanced growth hormone and IGF-1 levels support muscle growth and maintenance. Improved Recovery: Faster healing and reduced muscle soreness after workouts or injuries. Reduced Fat Storage: Accelerated fat metabolism for improved body composition. CJC 1295 has a longer-lasting effect. Hexarelin is best for short-term use when rapid results are required, but it carries a higher risk of side effects and tolerance. CJC-1295 DAC, also known as DAC:GRF (short for drug affinity complex:growth hormone-releasing factor), is a synthetic analogue of growth hormone-releasing hormone (GHRH) (also known as growth hormone-releasing factor (GRF)) and a growth hormone. What are the benefits of hexarelin? Hexarelin treatment significantly improved glucose and insulin intolerance and decreased plasma and liver triglycerides in MKR mice. FAST SHIPPING WORLD WIDE

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Growth Hormone Secretagogues

CJC-1295 + Ipamorelin (5/5mg) PEPTIDE SCIENCE IS AVAILABLE IN INDIA CJC-1295 DAC, also known as DAC:GRF (short for drug affinity complex:growth hormone-releasing factor), is a synthetic analogue of growth hormone-releasing hormone (GHRH) (also known as growth hormone-releasing factor (GRF)) and a growth hormone secretagogue (GHS) which was developed by ConjuChem Biotechnologies.[1][2][3] It is a modified form of GHRH (1-29) with improved pharmacokinetics, especially in regard to half-life. 1. Primary Uses ✅ Muscle Growth & Performance Enhancement Boosts lean muscle mass by increasing protein synthesis. Speeds up recovery from workouts or injuries (tendons, ligaments). Popular among athletes, bodybuilders, and fitness enthusiasts. ✅ Fat Loss & Metabolism Enhances lipolysis (fat breakdown), especially stubborn belly fat. Improves insulin sensitivity (beneficial for metabolic health). Anti-Aging & Longevity Stimulates collagen production → Firmer skin, reduced wrinkles. Supports joint health → Reduces age-related stiffness/pain. May improve sleep quality & cognitive function (GH regulates brain health). ✅ Injury & Tissue Repair Accelerates healing of muscles, tendons, and cartilage. Used by athletes recovering from strains or surgeries. SKYBLUE INTERNATIONAL is a trusted global pharmaceutical export company specializing in the export of high-quality medicines. With a strong commitment to healthcare excellence, we supply a wide range of branded and generic medicines to countries including the USA, UK, Australia, UAE, Canada, Singapore, and the Philippines. Our focus is on reliability, compliance, and timely delivery to meet the global demand for affordable and effective medical solutions. Medicine WE EXPORT TO SINGAPORE WE EXPORT TO AUD WE EXPORT TO CAD WE EXPORT TO UK WE EXPORT TO UAE

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early analogue substituted?