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'action dual agonist'

Items tagged with 'action dual agonist'

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Diabetes & chronic weight management

TIZARO TIRZEPATIDE 12.5mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, EUROPE, UAE Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Type 2 Diabetes Management: Tizaro is prescribed to improve blood sugar control in adults with type 2 diabetes, as an adjunct to diet and exercise. Weight Loss: It is also used for weight loss in adults with obesity or overweight, sometimes with weight-related conditions. Tirzepatide, the active ingredient in Tizaro, is a dual GIP and GLP-1 receptor agonist. It mimics the actions of these gut hormones, which regulate blood sugar levels and appetite. Administration: Tizaro is injected under the skin (subcutaneously). It is typically administered once a week. Patients should be instructed on proper injection techniques. Tizaro (Tirzepatide) 15mg is a prescription injection used to manage type 2 diabetes and also for weight loss in adults. It works by mimicking gut hormones that help regulate blood sugar and appetite. It is administered once weekly via subcutaneous injection. BUY FROM US WORLD WIDE SHIPPING WITH GOOD PACKAGING CONTACT US FOR BEST OFFERS & DEALS

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Sexual & Reproductive Health Peptide

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+919529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Generic Name Bremelanotide 1. Hypoactive Sexual Desire Disorder (HSDD) in Women FDA-approved in 2019 under the brand Vyleesi for pre-menopausal women with generalized HSDD unrelated to other medical or psychological condition Improves sexual desire, arousal, and reduces distress linked to low libido 2. Erectile Dysfunction (ED) in Men (Off‑Label) PT‑141 initiates erections via central nervous system pathways, increasing sexual desire and erection quality—even in men unresponsive to PDE‑5 inhibitors Demonstrated increased duration and rigidity of erections in trials 3. Sexual Arousal Support Boosts libido in both genders, addresses low sexual drive and arousal disorders, potentially enhancing orgasm quality and reducing refractory time Bremelanotide is a 7 amino acid peptide used to treat hypoactive sexual desire disorder in premenopausal women. Bremelanotide does not interact with alcohol. The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown. Bremelanotide was first described in the literature in 2003 when it was known by the investigational code PT-141.1 Since then it was investigated for its place in treating sexual dysfunction in men and women but is now only indicated for women.1,2,5 Other drugs used to treat female sexual dysfunction include flibanserin, estrogen, ospemifene, and prasterone. Bremelanotide was granted FDA approval Bremelanotide is an agonist of many melanocortin receptors which in order of potency are MC1R, MC4R, MC3R, MC5R, and MC2R.5 The mechanism by which agonism of these receptors translates to an improvement in hypoactive sexual desire disorder is currently unknown, however MC4R receptors are present in many areas of the central nervous system. MC3R and MC4R are found in the hypothalamus and are involved in food intake and energy homeostasis. Bremelanotide is a 7 amino acid and so its metabolism consists of multiple hydrolysis reactions.

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Neurological & Cognitive Peptides

P21 (P021) 5mg Peptide mechanism of Action Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+917499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Product Name P21 Peptide (a.k.a. P021) Common Dosage Form 5mg lyophilized powder per vial Type Synthetic neurotrophic peptide Molecular Formula Varies (not publicly disclosed due to proprietary status) Molecular Weight ~1,200–1,800 Da (estimated, depending on modification) CAS Number Not officially registered (research compound) Sequence Proprietary — derived from a CNTF (Ciliary Neurotrophic Factor) analog Purity ≥ 98% (HPLC tested) Peptide Content ≥ 90% Appearance White to off-white lyophilized powder 🧠 Primary Uses of P21 (5mg): 1. Cognitive Enhancement (Nootropic Use) Improves memory, learning speed, and mental clarity Supports executive function and attention span Often used by individuals looking to combat brain fog or age-related decline 2. Neurogenesis & Brain Repair Promotes growth of new neurons (neurogenesis) and synaptic plasticity May help in recovery from brain injury, stroke, or trauma 3. Neuroprotection Reduces oxidative stress, inflammation, and cell death in brain tissues Protects neurons from degenerative conditions like Alzheimer’s or Parkinson’s (in animal models) 4. Mood and Motivation May increase dopaminergic activity, supporting motivation, drive, and emotional balance Anecdotal reports suggest reduced anxiety and depressive symptoms 5. Combating Age-Related Cognitive Decline Potential anti-aging effects on brain structure and function May increase levels of BDNF (Brain-Derived Neurotrophic Factor) ⚙️ Mechanism of Action Mimics and enhances CNTF (Ciliary Neurotrophic Factor) signaling Promotes neural stem cell differentiation Boosts BDNF and NGF (nerve growth factor) activity Inhibits pathways involved in neuronal apoptosis (cell death) buy from us at best price

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Metabolic & Weight Management Peptides

Contact Us on telegram or WhatsApp ‪+917887449821‬ ‪+919168783773‬ ‪+91 9529672584‬ ‪+91 7499402610‬ Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ AOD9604 5mg retains the bone stimulating properties of human Growth Hormone. AOD9604 indicates that this drug may have a role in the prevention and possible treatment of osteoporosis, through direct action on osteoblasts, the cells which build new bone. AOD 9604 (5mg) is a synthetic peptide derived from the C-terminal fragment of human growth hormone (hGH). It has been studied for its potential benefits in fat metabolism and weight management. ✅ Uses of AOD 9604 Fat Loss and Weight Management AOD 9604 has been shown to stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (the formation of new fat), potentially aiding in fat loss and weight management. Targeted Fat Reduction The peptide may help reduce fat in specific areas, such as the abdominal region, by promoting the breakdown of stored fat. Improved Metabolism AOD 9604 may enhance metabolic rate, leading to increased calorie burning and potentially supporting weight loss efforts. Muscle Preservation Unlike some weight loss methods, AOD 9604 may help preserve lean muscle mass during fat loss, contributing to improved body composition. Bone and Cartilage Repair Some studies suggest that AOD 9604 may have regenerative properties, potentially aiding in the repair of bone and cartilage tissue. Enhanced Exercise Recovery The peptide may support faster recovery from exercise-induced muscle damage, reducing soreness and improving performance. ⚠️ Important Considerations Administration: AOD 9604 is typically administered via subcutaneous injection Dosage: Common dosing ranges from 300–500 mcg per day, depending on individual goals and protocols. Duration: Treatment cycles often last between 4 to 12 weeks, followed by breaks to assess effectiveness and reduce potential side effects. Consultation: It's crucial to consult with a healthcare professional before starting AOD 9604 therapy to ensure it's appropriate for your individual health needs and goals. AOD 9604 peptide therapy is considered a safe and effective solution for weight loss.

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Metabolic & Weight Management Peptides

Tirzepatide (60mg) FAST DELIVERY TO FLORIDA Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.skyblueinternationals.com/ Tirzepatide (60mg) Uses: Type 2 Diabetes: Tirzepatide is used to improve blood sugar control in adults with type 2 diabetes, often used with diet and exercise. Weight Management: It is also used for weight loss, particularly in adults who are overweight or obese, or who have weight-related medical problems. a synthetic peptide, a dual agonist for both GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide) receptors. It is used to treat type 2 diabetes and may also be used for weight management. It works by mimicking the effects of two hormones involved in glucose regulation and appetite control, helping to lower blood sugar levels and potentially leading to weight loss. Tirzepatide is administered as a once-weekly subcutaneous injection. Dual Action: Tirzepatide targets both GLP-1 and GIP receptors, enhancing insulin sensitivity and potentially leading to weight loss. Mechanism of Action: It increases insulin secretion when blood sugar is high, lowers liver glucose production, and slows down food movement through the digestive tract, contributing to blood sugar control and weight loss. Administration: Tirzepatide is a subcutaneous injection, given once weekly. Potential Side Effects: Common side effects include nausea, vomiting, diarrhea, and constipation, especially during the initial dose escalation phase. Top Benefits of Tirzepatide :- Powerful Blood Sugar Control (Type 2 Diabetes) Lowers HbA1c levels significantly (up to 2.4% reduction) Helps regulate insulin and glucagon more effectively than GLP-1 drugs alone Outperforms other drugs like semaglutide and insulin degludec in trials

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Metabolic & Weight Management Peptides

TO BUY Tirzepatide (40mg) Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com Internationalskyblue@gmail.com Viwe our catalog :- https://wa.me/c/917499402610 Tirzepatide is a dual agonist for the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors. The drug leads to significantly improved glycemic control and weight reduction in patients with T2DM, maximizing benefits similar to GLP-1 medications such as semaglutide. Tirzepatide (Zepbound brand) is used for weight loss, to help lose weight and keep weight off. Tirzepatide works for weight loss by decreasing appetite and slowing the movement of food from the stomach into the small intestine, which may make you feel full more quickly and for a longer period. The Zepbound brand of tirzepatide is also used for moderate to severe obstructive sleep apnea (OSA) in adults with obesity. Tirzepatide is a once-weekly injection given under the skin using a pen (autoinjector). Zepbound (tirzepatide) is FDA-approved for weight loss in adults with obesity or who are overweight and have weight-related medical problems or OSA. Zepbound helps you to lose weight and maintain weight loss and should be combined with diet and exercise. Tirzepatide (Mounjaro brand) is used for type 2 diabetes to help improve blood sugar levels. In type 2 diabetes, tirzepatide decreases blood sugar levels by helping release insulin when blood sugar levels are high, lowering the amount of sugar the liver makes, and slowing food movement through the intestines. Mounjaro should be used together with diet and exercise. Mounjaro (tirzepatide) is FDA-approved to treat adults with type 2 diabetes and should be used together with diet and exercise. It can be used as a single therapy (on its own) or with other diabetes medicines, including sulfonylureas, SGLT2 inhibitors, or metformin. It is not known if tirzepatide can be used in people who have had pancreatitis. Tirzepatide should not be used in people who have type 1 diabetes. Normally, when we eat, natural hormones called GIP and GLP-1 are released by the gut. These hormones increase insulin release, suppress appetite, slow gastric emptying, and increase the feeling of fullness. Tirzepatide works like our natural hormones GIP and GLP-1 by activating the GIP and GLP-1 receptors. Tirzepatide is a GIP and GLP-1 receptor agonist. Tirzepatide works (mechanism of action) by activating both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors. Weight Loss Achieved: tirzepatide: 64.6% of participants lost 15% of their weight semaglutide: 40.1% of participants lost 15% of their weighT Tirzepatide (40mg) USE FOR WEIGHT LOSS Mechanisms: Increases insulin release in response to glucose Reduces glucagon secretion Slows digestion to avoid sugar spikes

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Metabolic & Weight Management Peptides

Tirzepatide (20mg) Peptide Science |USES|DOSES|SIDE EFFECT FAST DELIVERY TO UNITED KINGDOM Contact Us on telegram or WhatsApp +917887449821 +919168783773 +91 9529672584 +91 7499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://wa.me/c/917499402610 Tirzepatide (20mg) USES : -Tirzepatide injection is used to treat type 2 diabetes. It is used together with diet and exercise to help control your blood sugar. Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide is a next-generation medication that acts as a dual agonist of GLP-1 and GIP receptors. It is approved for medical use under the brand name Mounjaro and is also available from research peptide sources (often as a 20mg vial). Chronic Weight Management (Obesity/Overweight) Approved by the FDA in 2023 under the name Zepbound For adults with: BMI ≥30, or BMI ≥27 with weight-related conditions (e.g., hypertension, sleep apnea, dyslipidemia) Shown in clinical trials to result in >20% average body weight loss at higher doses Studying fat loss mechanisms Investigating insulin resistance Testing combination therapy potential with GLP-1 analogs Exploring impacts on metabolic syndrome, NAFLD, and cardiovascular biomarkers 💉 Dosing Guidance (Clinical Reference) Week Typical Dose Weeks 1–4 2.5 mg weekly Weeks 5–8 5 mg weekly Weeks 9+ Increase by 2.5 mg every 4 weeks up to 15 mg weekly (max dose for Mounjaro/Zepbound) FAST DELIVERY IN UNITED KINGDOM FROM SKYBLUE INTERNATIONAL

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Erectile Dysfunction Medicines

TADALAFIL & DAPOXETINE EXTRA SUPER VIDALISTA 100mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, UK, EUROPE, UAE & GET 20% OFF ON BULK ORDER Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.medicinesfromindia.com/ Erectile Dysfunction (ED) Tadalafil (PDE‑5 inhibitor) relaxes penile blood vessels, improving erections during sexual stimulation Premature Ejaculation (PE) Dapoxetine (an SSRI) delays ejaculation, boosting control and satisfaction Dosage & How to Use: Available in strengths like 40 mg tadalafil + 60 mg dapoxetine or 60 mg + 30 mg, and 80 mg + 40 mg. Take 1 tablet orally about 30–60 minutes before sex, not more than once in 24 hours Can be taken with or without food; avoid alcohol, grapefruit juice, and heavy meals Additional Benefits Dual-action therapy—simultaneously tackles ED and PE to improve overall sexual health and satisfaction. Extended performance window—tadalafil effect may last up to 36 hours, while dapoxetine adds ejaculatory control BUY IT NOW

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Erectile Dysfunction Medicines

TADALAFIL, VIDALISTA 40mg BUY IN CANADA, SINGAPORE, AUSTRALIA, USA, UK, EUROPE, UAE & GET 20% OFF ON BULK ORDER Contact Us on telegram or WhatsApp ‪ +917887449821‬ ‪ +919168783773‬ ‪ +919529672584‬ ‪ +917499402610 Mail :- skyblueinternational033@gmail.com internationalskyblue@gmail.com Viwe our catalog :- https://www.medicinesfromindia.com/ Mechanism of Action: Tadalafil, the active ingredient in Vidalista 40mg, belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. These medications work by relaxing the muscles in the penis and increasing blood flow, which facilitates an erection when a man is sexually aroused. Vidalista 40mg, containing the active ingredient Tadalafil, is primarily used to treat erectile dysfunction (ED) in men. It helps men achieve and maintain an erection by increasing blood flow to the penis. Tadalafil is a PDE5 inhibitor and is also sometimes prescribed for symptoms of benign prostatic hypertrophy. Erectile Dysfunction (ED): Vidalista 40mg is commonly prescribed to help men with ED achieve and sustain an erection sufficient for sexual intercourse. Mechanism of Action: Tadalafil works by inhibiting the PDE5 enzyme, which helps relax the muscles in the penis and allows for increased blood flow. Dosage and Administration: Typically, Vidalista 40mg is taken orally at least 30 minutes before sexual activity. The typical maximum dose for ED is 20mg, and taking 40mg could potentially increase the risk of side effects. It's crucial to follow the dosage instructions provided by a healthcare professional. Erectile Dysfunction (ED) Aids in achieving and sustaining an erection when there’s sexual stimulation, thanks to increased blood flow to the penis. Typically taken 30–60 minutes before intercourse, with effects lasting up to 36 hours—often dubbed the “weekend pill” Benign Prostatic Hyperplasia (BPH) Relaxes bladder and prostate muscles, alleviating urinary issues like weak stream, frequent urges, and hesitancy Pulmonary Arterial Hypertension (PAH) (dosages around 40 mg daily) Helps relax pulmonary blood vessels, lowering lung artery pressure and improving exercise capability

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